I didn't see a topic about artemisin yet, so I am opening one.
On the following link is a journal regarding antitumor acitivty or artemisin:
It is fairly long, I will just copy paste some parts:
"Artemisinin and its analogs are naturally occurring antimalarials which have shown potent anticancer activity. In primary cancer cultures and cell lines, their antitumor actions were by inhibiting cancer proliferation, metastasis, and angiogenesis. In xenograft models, exposure to artemisinins substantially reduces tumor volume and progression.
One major obstacle for a successful anticancer therapy is the development of resistance over time. Many aggressive tumors become refractory to anticancer therapy with hardly any chemotherapeutic alternatives. A leading cause of drug resistance is the drug efflux generated by overexpression of membrane protein pumps, which results in ineffective low drug concentrations . Anticancer activity of artemisinins has shown to be unaffected in otherwise resistant and multiresistant cancer cells"
I came across artemisin when friend's grandfather got me a tea from artemisia annua ( https://en.wikipedia.org/wiki/Artemisia_annua ), he also said I should take iron supplement when I drink it - folk's medicine like Stephen calls it :)
"In most of the systems, preloading of cancer cells with iron or iron-saturated holotransferrin (diferric transferrin) triggers artemisinin cytotoxicity [32–35] with an increase in artemisinin activity up to 100-fold in some cell lines .
Continued proliferation and growth of malignant cells require higher iron metabolism to achieve processes of cell survival . Therefore, cancer cells exhibit an increase in transferrin receptors (TfR) which are responsible for the iron uptake and regulation of intracellular concentrations. Levels of expression of TfR in cancer cells may vary depending on the cell line. However, they differ substantially from normal cells leading to a high selectivity index of artemisinin and its derivatives. Efferth et al. reported that leukemia (CCRF-CEM) and astrocytoma (U373) cells express TfR in 95% and 43% of the cell population, whereas normal monocytes only account for approximately 1% [42, 43]. "
Does anyone have any experience or knowledge on artemisin?