Saturday, 14 November 2015

Drug could limit spread of deadly brain tumors

Study shows PPF could help treat glioblastomas by sensitizing tumors to chemotherapy, radiation treatments

November 13, 2015
The Translational Genomics Research Institute
In a significant breakthrough, researchers have identified a drug, propentofylline or PPF, that could help treat patients with deadly brain cancer. They report that PPF works to limit the spread of glioblastoma multiforme, or GBM -- the most common primary tumor of the brain and central nervous system -- by targeting a protein called TROY.
Not sure if any one else already posted. Believe it says it's already been FDA approved. So, may be something to consider adding to a cocktail? Thoughts? 
  1. Hope I posted this right as first time trying. :-)


  1. I've discussed this drug on Astrocytoma Options, as it had been studies in rat models of GBM.

    My understanding is that it is used as a veterinary drug (for dogs). I may be wrong but I don't believe it's approved yet for human uses. I'll look into that some more.

  2. I read this in the article:
    "An advantage of small-molecule PPF -- which has been previously used in clinical trials in an attempt to treat Alzheimer's disease and dementia -- is that it can penetrate the blood-brain barrier and reach the tumor. And, the FDA has already approved it."
    Maybe they have it wrong or I misunderstood it? (Can very well be as I m not as versed as u all!) all I know about it is what I ve just read.

  3. The article indeed says that it's FDA approved, but I can find no mention of propentofylline or Vivitonin on the list of FDA-approved drugs available at the FDA website. There are different layers of FDA approval. A drug needs to have some form of approval even to make it into clinical trials. As far as I'm aware this drug hasn't been approved for any human indication, although if anyone has information to the contrary please let us know.

    1. In the UK the drug falls under the category POM-V which means

      "A Veterinary Medicinal Product (VMP) that has been classified as a POM-V may only be supplied to the client once it has been prescribed by a veterinary surgeon following a clinical assessment of an animal, or group of animals, under the veterinary surgeon's care."

      So you need a prescription even for your dog.


  4. Does anybody knows if Pentoxifylline has the same action mechanism? It's used for treat dementia I can get it easilly here in Argentina. Maybe I can get Propentofylline from vet friend too.