Friday, 6 May 2016

Please comment: Our first cocktail

Dear Stephen and all,

Thank you for all your advice and comments so far. Here's the cocktail we have almost finalized and would like final comments from you on any contra-indication or obvious misses or mismatched combinations.  Mom is 62 yrs old and has left side body paralyzed and low blood pressure. Her Ferretin and Glucose remain high in Blood Count. Early gene test reveled IDH1 inactive, MGMT methylated and EGFR amplified. More details will be known only a month from now. We plan to introduce this cocktail slowly to her starting this weekend. Her radiation just started.

Temodar (110 mg every day - 7 days a week)
Chloroquine (250 mg)
Disulfiram ((250 mg)
Celebrex (200 mg)
Depakote (1000 mg)
Melatonin  (10 mg)
Minocycline (200 mg)
Prozac
Steroids (1 mg a day that I want to remove once the doctor agrees)

Hemp Oil
PSK / PSP Mushroom
Pterostilbene
Curcumin
Fish Oil
Boswellia Serrate
Shark liver Oil
Beberine
Selenium
Honokiol
Ruta 6c
Vitamin D3
Green Tea extract
Broccoli Sprouts Extract
Lycopene
Quercetin

In store for possible swaps or future use:  Metformin, Prilosec, Tagamet, Auronafin.  I had to fight many different options to get these all, but have it now for 2 months supply atleast.

I am no expert - learnt from you all. So please comment if I should consider any swaps or missed out anything.

best, JR


11 comments:

  1. Hi JR -

    We did copper with disulfuram. I think 20mg? Someone can correct me if that dose is inaccurate. I read that copper enhanced the Disulfiram effectiveness. Dad also takes lycopene, pterostilbene, and quercetin. Also DCA.

    I think your list looks good.

    Best
    Annie

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  2. I defer to Stephen on DCA dosing :-) Dad takes about 1.6 mg per day. I don't know if he has any side effects because he has severe aphasia and can't easily communicate with us. His right side is basically dead weight so I'm not sure if he's experienced any neuropathy or not.

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  3. Keytruda, cannabis cbd/thc if possible and Valcyte, the rest looks ok .

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  4. HI Rumi,
    Any suggestion on how to arrange for Keytruda? Seems like prescription I.V. right? Did Oncologist agree or primary doctor or integrative doctor or some other source? thx

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    Replies
    1. Hi yes prescription Iv, no one answer, how and at what priceall depends on where you are in the world. In the uk there is an access program, in the us another method, But all are accessible in one way or another.

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  5. Chloroquine, Depakote and melatonin have been used (respectively) in glioma trials during radiation, and there is also good theoretical support for using COX-2 inhbitors (like Celebrex) during radiation. Doctors don't like to prescribe NSAIDs (like Celebrex) and corticosteroids (like dexamethasone) together, due to concern over increased risk of gastrointestinal problems, although this may be more of a problem with non-selective COX inhibitors rather than selective COX-2 inhibitors like the coxibs. If she is able to get off steroids all together, that is even better.

    There is also good theoretical support for disulfiram during radiation although I've not heard of anyone trying this (perhaps someone on this blog has taken disulfiram during radiation?). So keep in mind this would be quite experimental.

    THC/CBD combined with radiation was highly effective in a glioma mouse model.

    Berberine could help with her high glucose levels, as could metformin.

    The main use I've heard about for shark liver oil is as a platelet booster, which is often more of a problem during the monthly cycles of high dose TMZ (5/23 schedule).

    You may want to consider pterostilbene, as a more highly bioavailable nutraceutical in place of, or in addition to, resveratrol.

    I like the idea of minocycline during and after radiation, and there is currently GBM trials testing this approach:

    https://clinicaltrials.gov/ct2/show/NCT02272270

    Tagamet (cimetidine) can effect the metabolism and clearance of other drugs, leading to higher plasma levels than would otherwise be expected, but these effects are usually moderate, and dosages can be adjusted accordingly.

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  6. Thank you all.

    We added Prozac, Minocycline, Pterostilbene, THC/CBD, Lycopene and Quercetin to the mix.

    Took out Dexa (steroids), Reservatrol, Curcumin and Boswellia.

    I am ordering DCA to keep it in stock and trying to figure out how to get Valcyte and Keytruda.

    I do have Metformin in stock -- not sure if I should load up so much though. What would you recommend between Celebrex and Metformin during radiation?

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  7. Dad took Disulfiram during radiation. No known issues. Radiation almost killed my dad (swelling) towards the end but I don't believe this was the cocktail. He was able to rebound by upping the dex.

    Dad also took Metformin and Celebrex during radiation and takes them still. We do 2 Celebrex capsules twice daily (4 total) and 2 Metformin daily. Our only chemo now is Avastin.

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  8. There have been several studies that conclude that CBD (cannabidiol) is beneficial in the fight against cancer while taking Keytruda. We have seen many patients that are showing greater reductions of cancer levels with the CBD than with just the Keytruda.

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    Replies
    1. Could you provide a link to one of these studies?

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    2. I would also like to see that study. My understanding is that THC is what's needed to reduce swelling and possible cancer growth and CBD is helpful for pain control.

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