Thursday 19 May 2016

volasertib

Hi all dose anyone have any information about volasertib?
I have been researching it recently and it seams promising 

5 comments:

  1. Volasertib is a Polo-like kinase inhibitor, which is a valid target in GBM, but it doesn't have full FDA approval yet, so it would likely be very difficult to get this outside of a clinical trial.

    Another drug that downregulates Polo-like kinase is disulfiram:

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717961/

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  2. Stephen do you know is disulfiram inhibits plk-1 ? As opposed to other plk family members ?

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  3. " Consistent with its role in suppressing GBM growth, DSF inhibited the expression of PLK1 in GBM cells"

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  4. Has there been any human trails using dsf?

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  5. Yes, there was a phase 1 dose-finding trial in GBM just published.
    http://www.ncbi.nlm.nih.gov/pubmed/26966095

    However, no copper was added in these patients. As part of the same trial, copper + disulfiram is now being combined but no results have been published for that arm of the trial yet.

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