Wednesday, 19 October 2016

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

Link to article:

Aynone taking l-arginine and your  thoughts on supplementation?


  1. Interesting article. The "survival" here refers to the survival to T lymphocytes, not animals or patients. By itself, this might suggest a benefit to taking supplemental arginine.

    However, there's a line of research that suggests many cancers (including gliomas) are dependent on exogenous arginine to function. Indeed, depletion of arginine availability to glioma cells may be a promising avenue of research. As just one example, see:
    "Arginine deprivation by arginine deiminase of Streptococcus pyogenes controls primary glioblastoma growth in vitro and in vivo"

    So, would we expect arginine supplementation to be helpful (by stimulating lymphocytes) or harmful (by stimulating glioma cells)? Darned if I know. But personally, I don't think I'd recommend trying such supplementation. "First, do no harm."

  2. Thanks for your (helpful) insight :)