Hi All, anyone heard of photodynamic therapy? I read about sone Australian studies that had considerable success with it. Anyone tried it? If yes, can you please share information: where and whether it was effective?
Many thanks
Noha
Many thanks
Noha
The forefront of photodynamic therapy for glioma seems to be Japan now. There've been some interesting abstracts published in the past few years. See my summary in the Photodynamic Therapy section of Ben Williams Treatment Options update 2016.
ReplyDeletehttp://virtualtrials.com/pdf2016/benwilliamsTreatmentOptionsUpdate2016.pdf
The Japanese are using talaporfin sodium, a second generation photosensitizer, while the recently reopened trial in Wisconsin is still using Photofrin, a first genereration photosensitizer similar to the one used in the Australian study.
https://clinicaltrials.gov/ct2/show/NCT01966809
Thanks Stephen. There is now next generation photodynamic therapy that is believed to be more powerful. The advanced agents used called photosoft are metabolized and cleared from the body within 24 hours so the patient doesn't need to hide from light and sun for weeks as used to be the case with the first and second generation agents.
ReplyDeletenext generation of PS also claims not to require invasive endoscopic treatment procedures. They claim that Because these photosensitizers are so much more light-reactive and efficient they can be activated from outside the body, reducing or eliminating the need for direct illumination via fiber-optic catheters.
My fear is that with patients who have alot of tumor burden ( like my husband does) and it is inoperable, can it cause cerebral edema and swelling complications?
Thanks Stephen!
Noha
Could you provide a link or source for this information? Thanks.
DeleteHere you go:
ReplyDeletehttp://www.nextgenerationpdt.com/brochures/ngpdt_brochure.pdf
I was told it is available in China, Japan and Australia
Just read the brouchure sounds very interesting
ReplyDeleteI spoke with them and they said my husband doesn't qualify because of the big tumor burden. This can lead to immune response and swelling
ReplyDeleteAcridine Orange as a Novel Photosensitizer for Photodynamic Therapy in Glioblastoma.
ReplyDelete2018 https://www.ncbi.nlm.nih.gov/pubmed/29631084
"Acridine orange is a molecule with fluorescence properties that was demonstrated to possess photosensitizing properties."
"A dramatic cytocidal effect of acridine orange after exposure to as little as 10 minutes of white light was observed. There was almost complete eradication of the glioblastoma cells over a 72-hour period."