Thursday, 3 December 2015

Alfacalcidol D3

As part of his cocktail my husband has been taking 1mg of Alafacalcidol (vitamin D3) for almost two months now. Now I am not sure if this is the right dosage? It comes in capsules of 0.25mcg.

8 comments:

  1. I think you meant to write 1 mcg alfacalcidol (rather than 1 mg). In the French study from 2001, the dose was 0.04 mcg/kg per day. For a man weighing 65 kg, that would work out to 2.6 mcg per day. I think you could go up to 2 mcg per day at least, but bloodwork should include testing for hypercalcemia.

    In the GBM study using the 0.04 mcg/kg dose, there was no evidence of hypercalcemia in any of the patients after months of use.

    http://www.ncbi.nlm.nih.gov/pubmed/11349882

    I'll upload a copy of this to the Library.

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    1. Thank you Stephen, and yes, I meant 1mcg! Sorry. Actually I think I have already looked at this study previously and came up with 3.6mcg for my husband. This sounded a lot to me, but I think we will go up since there was no evidence of hypercalcemia...

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    2. HopeST - Do you mind me asking where you get your alphacalcidol?

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    3. Can someone share with me a source for alphacalcidol?

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    4. This is approved in Canada but not in the USA. You could get in through any number of Canadian pharmacies

      https://www.canadadrugs.com/products/one-alpha
      https://www.universaldrugstore.com/medications/One+Alpha/0.25mcg
      https://www.northdrugstore.com/buy-One-Alpha.html

      but you'd likely need a prescription first.

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  2. Also one have to check renal function (estimated GFR using CKD-EPI with blood tests, and ultrasound)!

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    1. One advantage of alfacalcidol (which is a calcitriol prodrug) over vitamin D3 is that it doesn't require activation by the kidneys - it is converted into calcitriol directly by the liver. This means alfacalcidol is useful even for people with reduced kidney function.

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    2. Granted, the indicated use of alfacalcidol in Canada is "management of hypocalcemia, secondary hyperparathyroidism, and osteodystrophy in patients with chronic renal failure" so using it for patients with normal renal function would be an off-label use.

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