http://www.ajtr.org/files/ajtr0024896.pdf
"Finally, metformin treatment dose-dependently reduced glioma induced vascular permeability and cerebral edema in vivo in rats. Thus, our results suggested that metformin may protect endothelial cell tight junction, prevent damage to the blood brain barrier induced by brain tumor growth, and alleviate the formation of cerebral edema."
The rats were fed metformin dissolved in their daily drinking water.
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