http://www.ncbi.nlm.nih.gov/pubmed/23564811"The trial was terminated at 13 patients, according to the planned two-stage design, because 0/10 patients obtained partial remission (PR). Two out of 10 patients obtained radiological stable disease (SD).""Temsirolimus can be safely administered in combination with bevacizumab. This study failed to detect activity of such a combination in patients with progressive GBM beyond bevacizumab therapy."
Thanks Steve. I saw this too. My husband's No shared another study with partial response but unfortunately unsustainable!What do I try after trying multiple gamma knife, multiple radiation, 5/23 temodar, daily temodar, CCNU, carob platin, avastin, PD1 and even ipilimumab!!!
Given you've tried all the conventional treatments, I'd be looking into some of the more experimental approaches, like thyroid hormone T4 suppression, or propranolol + etodolac + low dose TMZ as in this abstract: http://meetinglibrary.asco.org/content/151704-156No guarantees with any of these treatments, but probably worth trying.
Thanks Stephen. Will have to convince his NO to go back to metronomic temodar.. We tried that too at one point. Nothing worked. Do you have any information about the thyroid hormone T4 suppression in gbm? Thanks a mill
Yes, I've uploaded studies into folder 1 of the Brain Tumor Library.https://drive.google.com/drive/u/0/folders/0B5NygvEcCgmyd3ZnbzdHaVppX2M