Prolonged blocking of Ezh2 could lead to tumor progression
EDIT: I just edited the post title, to reflect what the article really says, and avoid spreading false information. Thanks Stephen!
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"Prolonged Ezh2 Depletion in Glioblastoma Causes a Robust Switch in Cell Fate Resulting in Tumor Progression"
by
Nienke A. de Vries , Danielle Hulsman , Waseem Akhtar , Johann de Jong , Denise C. Miles , Marleen Blom , Olaf van Tellingen , Jos Jonkers , Maarten van Lohuizen
Matias, This article is not saying that doxycycline alone would lead to tumor progression. It is saying that blocking Ezh2 has those effects. In this study the technology they used to block Ezh2 was shRNA (small hairpin RNA) that selectively depletes the Ezh2 protein. This technology depends on the use of doxycycline.
http://www.ncbi.nlm.nih.gov/pubmed/23563548
These effects would NOT be seen with doxycycline alone, without the use of shRNA technology.
I guess tumors always try to find a way around what´s being thrown at them, but to know about this very concrete case is scary!
ReplyDeleteMatias,
ReplyDeleteCould you post the title of the study so I can look it up. I'm having trouble with the link.
Steven, here is is. http://www.cell.com/cell-reports/pdf/S2211-1247%2814%2901057-2.pdf
ReplyDelete"Prolonged Ezh2 Depletion in Glioblastoma Causes a Robust Switch in Cell Fate Resulting in Tumor Progression"
ReplyDeleteby
Nienke A. de Vries
, Danielle Hulsman
, Waseem Akhtar
, Johann de Jong
, Denise C. Miles
, Marleen Blom
, Olaf van Tellingen
, Jos Jonkers
, Maarten van Lohuizen
(sorry for lack of formatting)
Matias,
ReplyDeleteThis article is not saying that doxycycline alone would lead to tumor progression. It is saying that blocking Ezh2 has those effects. In this study the technology they used to block Ezh2 was shRNA (small hairpin RNA) that selectively depletes the Ezh2 protein. This technology depends on the use of doxycycline.
http://www.ncbi.nlm.nih.gov/pubmed/23563548
These effects would NOT be seen with doxycycline alone, without the use of shRNA technology.
Phew! It´s very good to know, Stephen! But doesn´t doxycycline also deplete Ezh2?
ReplyDeleteThanks for the review of this Steven. Matias, thank you for bringing it to our attention. Our group is an incredible and helpful group.
ReplyDeleteI have never heard or read of doxycycline alone being an inhibitor of Ezh2.
ReplyDelete