Yes, of interest. Thioridazine was also tested in a subcutaneous GBM mouse model recently.
"Identification of thioridazine, an antipsychotic drug, as an antiglioblastoma and anticancer stem cell agent using public gene expression data" http://www.ncbi.nlm.nih.gov/pubmed/25950483
The usual limitations apply in this glioma study: subcutaneous tumor implant rather than intracranial, intraperitoneal injection of the drug rather than oral application, the decades-old U87 cell line used in vivo rather than a low-passage patient-derived line. Still, thioridazine seems to keep coming up in glioma studies, and I'll be keeping an eye on this.
Targeting dopamine receptor 2 (DRD2) signaling in combination with temozolomide chemotherapy as a novel therapeutic concept in glioblastomas.
http://meetinglibrary.asco.org/content/152566-156
In which thioridazine improves TMZ sensitivity in an intracranial GBM mouse model. I would certainly like to see the poster for this if anyone finds it.
Yes, of interest. Thioridazine was also tested in a subcutaneous GBM mouse model recently.
ReplyDelete"Identification of thioridazine, an antipsychotic drug, as an antiglioblastoma and anticancer stem cell agent using public gene expression data"
http://www.ncbi.nlm.nih.gov/pubmed/25950483
The usual limitations apply in this glioma study: subcutaneous tumor implant rather than intracranial, intraperitoneal injection of the drug rather than oral application, the decades-old U87 cell line used in vivo rather than a low-passage patient-derived line. Still, thioridazine seems to keep coming up in glioma studies, and I'll be keeping an eye on this.
DOPAMINE ADDICTION IN GLIOBLASTOMA
ReplyDeleteMULTIFORME DURING CHEMOTHERAPY IS MEDIATED BY A
DRD2/beta-ARRESTIN/AKT SIGNALING COMPLEX
http://neuro-oncology.oxfordjournals.org/content/16/suppl_5/v65.4.abstract
Here the mechanism of action of thioridazine is not potassium-channel blocking but dopamine receptor inhibition.
And from this year's ASCO:
ReplyDeleteTargeting dopamine receptor 2 (DRD2) signaling in combination with temozolomide chemotherapy as a novel therapeutic concept in glioblastomas.
http://meetinglibrary.asco.org/content/152566-156
In which thioridazine improves TMZ sensitivity in an intracranial GBM mouse model. I would certainly like to see the poster for this if anyone finds it.