Sunday 13 September 2015
Memory problems anybody? Cocktail side effect?
My brother has memory problems. He forgets if he ate or not. They gave him one extra week of radiation because the tumor kept growing during the radiation. Also he is on the cocktail now and I am wondering if any of the cocktail ingredients could be causing it. I red something about omeprazole and Alzheimer link. Also people get high by taking omeprazole with some other agents. I am wondering if combining omeprazole with other agents could be causing it. Any suggestions. I am wondering what to take out from the cocktail. The good news is that the last Pet scan with choline looks better than the ct scan from June. The doctor who does not know about the drugs is very surprised. I am worried about the memory though I don't want to make it worse. Is it someting to be expected after radiation or maybe the extra things he is taking like ashwaganda or hepatometer combined with omeprazole? Please give your opinion :)
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According to this recent review, he might be better off taking more ashwagandha rather than eliminating it:
ReplyDeletehttp://www.ncbi.nlm.nih.gov/pubmed/26361721
I could probably obtain a copy of this and add it to the Library.
I will also create a Quality of Life folder in the Library and add this study, and a study of Gingko biloba for cognitive improvement. However, Gingko has potential interactions with a number of drugs so may be tricky to integrate into a cocktail.
Thank you Stephen.
ReplyDeletePlease see the Brain Tumor Library, new folder added (called Quality of Life) with 4 studies just uploaded. Anyone who would like access to the library (easiest if you have a Google account) can email me at the address found on the User Information page (see pages at top of the blog).
ReplyDeleteSome sources indicate that vit b1 deficiency can lead to memory loss. Could this be a result of dca with not enough vit b1?
ReplyDeleteMy husband's memory is worse since starting DCA in June, he takes 20mg / kilo, he is taking B1
ReplyDeleteOn the relation between DCA and thiamine deficiency see this early study by Peter Stacpoole et al:
ReplyDeleteChronic toxicity of dichloroacetate: possible relation to thiamine deficiency in rats
http://www.ncbi.nlm.nih.gov/pubmed/2318357
This quote is from a different review by Stacpoole:
"In addition, because DCA stimulates at least two thiamine-dependent
enzymes in vivo, pyruvate dehydrogenase and branched
chain a-keto acid dehydrogenase, Stacpoole et al reasoned that chronic DCA treatment might induce thiamine
deficiency through an increased demand for this vitamin and
found that coadministration of thiamine with DCA to rats
significantly reduced the incidence of hind limb weakness
and other behavorial changes typical of both DCA toxicity
and thiamine deficiency."
However a clinical trial found that supplementation with 10mg/kg thiamine (plus CoQ10, L-carnitine, alpha-lipoic acid) was not sufficient to protect against peripheral neuropathy in patients taking 25mg/kg/day of DCA.
Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial.
http://www.ncbi.nlm.nih.gov/pubmed/16476929
I will be uploading these studies to the library today. I realize that this doesn't directly address the question of memory deficiencies.
Studies uploaded to the Library: folder 4 (Therapies - Side effects)
ReplyDeleteSee "Korsakoff's syndrome", the loss of short-term memory caused by severe thiamine (vitamin B1) deficiency usually linked to heavy alcohol comsumption.
ReplyDeletehttp://www.alzheimers.org.uk/site/scripts/documents_info.php?documentID=98
Thank you Stephen. I think we will stop dca, omeprazole and cimetidine for a while to absorb more b1. Will see how it goes. It says that antacids can interfere with absorption of b1.
ReplyDelete