Monday 11 July 2016

Dendritic Cell Therapy?

Has anyone has success with DC therapy here in the states?

We are looking at Dr. Chang's offering here:
https://dendritic.info/

And the Issel's center here:
http://www.issels.com/

For Dr. Chang's offering, does one need to travel to Germany initially or can it all be done here? I know that his NCV offering requires travel to Germany, initially.

Anyone have any experience with either Chang or Issel for GBM?
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8 comments:

  1. Unknown11 July 2016 at 14:10

    There are open trials which use DC. Below is story of Sandra who took the DC pp65 (w/ tetanus) in 2006 and she is doing great today, Most DC PP65 trial participants are still in an early stage as phase two of this trial began in Fall 2015.

    http://www.northjersey.com/news/the-sole-survivor-fort-lee-woman-beats-the-deadliest-form-of-brain-cancer-1.1472960

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    Replies
    1. Logan Lo13 July 2016 at 04:20

      Thanks for the info - I actually read the article previously and didn't realize it was a DC therapy. Unfortunately, my wife's KS is too low to participate in any clinical trial.

      Delete
    2. Anonymous13 July 2016 at 12:57

      https://insight.jci.org/articles/view/87059

      DC vaccine + checkpoint inhibitors

      Delete
    3. Stephen W13 July 2016 at 13:49

      Thanks for posting this link. The study hasn't even appeared on pubmed yet.

      "To evaluate the relevance to established glioma, the effects of PD-1 blockade following DC vaccination were tested in intracranial (i.c.) glioma tumor–bearing mice. Treatment with both DC vaccination and PD-1 mAb blockade resulted in long-term survival, while neither agent alone induced a survival benefit in animals with larger, established tumors."

      Delete
    4. Stephen W13 July 2016 at 14:05

      This study is a must-read for anyone considering vaccines and PD-1 antibodies, esp if they are dealing with more than minimal residual disease.

      Delete
  2. lucy13 July 2016 at 15:57

    When I called issels.com few months back they told me that they don't have vaccines for brain tumors. I'm not sure if this is still the case.

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    Replies
    1. Logan Lo14 July 2016 at 08:53

      Thanks for the info - I think it's still the case as I couldn't find any mention of brain cancers with them.

      Delete
  3. Anonymous14 July 2016 at 12:31

    Logan,
    I called them and they said they don't treat primary Brain Cancers due to the side effect concerns around inflammation, edema in brain. I pushed them a bit, but they seem to be clear about it.
    I called up another one in Mexico and they do prepare a vaccine - I am waiting for more info. Their website is -- http://www.immunitytherapycenter.com/our-alternative-therapies/
    Let me know what you found out from Dr. Chang's office. We are in the same boat as my mom had left-side body paralyzed and therefore clinical trials entry is unlikely (they all ask for KPS score of 70 or above).

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