Alan's latest MRI showed progression. We are looking at a PD1 inhibitor. Can anyone tell me the difference between Keytruda and Nivolumab? Anybody with thoughts or experience with Gamma Knife.? Alan has only had the basic testing and is unmethylated and IDH1 negative.
The oncologist wants to stop avastin and start Keytruda but doesn't want to do them together. I read some data a while back indicating that if you stop Avastin when there is progression that the tumour grows extra fast . Oncologist says that is not the current thinking. Stephen do you have any information about this.
Linda
Keytruda (pembrolizumab) and Opdivo (nivolumab) are both monoclonal antibodies against PD-1, approved at about the same time (late 2014) for melanoma, but made by different companies. Until evidence shows superiority for one or the other, I'm considering them to be equivalent.
ReplyDeleteThere was a recent study on tapering and discontinuation of Avastin without tumor rebound, that I posted on the blog a few days ago. This provides evidence that tapering and even discontinuation of Avastin in the absence of progression can be safely achieved.
http://link.springer.com/article/10.1007/s11060-016-2206-x
I've uploaded this study to folder 1, Avastin subfolder of the Library.