Sunday, 21 August 2016

Curcumin rescues mice with GL261 mouse glioma syngrafts

The blue line represents survival of mice treated intranasally with an experimental curcumin-antibody conjugate.  The red line represents mice injected intraperitoneally with 100 mg/kg curcumin in the form of Meriva Curcumin phytosomes.  These treatments dramatically shifted the phenotype of microglia from a tumor-promoting M2 type to an anti-tumor M1 type.

from the study:
online August 20, 2016 in the International Journal of Cancer  

to be uploaded in the Brain Tumor Library, folder 2, Curcumin subfolder


  1. Wow, great news and hopefully further testing is pushed forward quickly. My question would be, how best could curcumin be appropriately delivered currently?

  2. Interesting, maybe we should cycle the Meriva form with the optimized Longvida curcumin form.

  3. The key question for us is how does one get that intranasal curcumin delivery? Not sure if that's a spray or injection. As we know -- the issue with curcumin is getting it into the bloodstream quickly (i.e. bioavailability).

    1. For the mice:

      "the mice were anesthetized, placed in the supine position, and 120 pmoles of CC-CD68 Ab adduct (containing 18 µg of CD68 Ab) dissolved in 30 µl of sterile 10 mM PBS was applied as 3-µl drops using a micropipette, alternately, every two minutes, to each nostril and allowed to be snorted in."

      Curcumin nasal sprays are available for sale, though I've not heard of clinical trials testing this method of administration.

  4. Our Dr. Zhang has Husband put Curcumin C3 Complex powder (from LIFEenhance) in nut butter and oils three times per day.

    His recipe (amts are approx since he just eyeballs them):

    3/4 tsp. Curcumin C3 Complex
    2 tsp. each of peanut, almond, and cashew butters
    2 tsp. Nature's Way raw coconut (sort of a coconut meat paste)
    2 tsp. Nature's Way coconut oil
    1 tsp. ghee

    He is a bit more generous with the butters and oils than Dr. Zhang originally recommended because he likes their taste and says they keep him from becoming constipated from the steroids.

  5. This is interesting. I think the medical system needs to revisit that intranasal pathway for drug administration. Very cool concept.

  6. From

    Nasal delivery

    To increase the bioavailability and also direct nose-to-brain drug transport, nasal delivery of curcumin has been used. In a study, the pharmacokinetics results showed that the absolute bioavailability of curcumin in the microemulsion-based in situ ion-sensitive gelling system was 55.82% by intranasal administration. And the distribution of curcumin in brain versus blood following intranasal administration was higher than that following intravenous administration [49]. Another study also showed that the drug-targeting efficiencies of the curcumin in the cerebrum, cerebellum, hippocampus and olfactory bulb after intranasal administration of the curcumin hydrogel were 1.82, 2.05, 2.07, and 1.51 times higher than intravenous administration of the curcumin solution injection, respectively, indicating that the hydrogel and intranasal administration significantly increased the distribution of curcumin into the rat brain tissue [50]."

  7. On the subject: does anyone know why bioperine isn't taken together even with Longvida formulation? In the journal that I posted above (Figure 3) there were higher concentrations of curcumin found in the brain of the mouse after bioperine addition to curcumin.

    1. Piperine (bioperine) inhibits the glucuronidation of unformulated curcumin, which as a major barrier to the bioavailability of free curcumin. That's not as big an issue for special formulations like Longivida which allows free curcumin to pass into the blood.

      "For example,
      oral gavage of an optimized, lipidated curcumin formulation
      (Verdure Sciences, Noblesville, IN; www.verduresciences.
      com) resulted in 11-fold higher levels of curcumin in plasma
      and 4-fold higher levels in brain compared with equal doses
      of curcumin powder or curcumin-piperine extracts."

      It might help somewhat though even with Longvida.

    2. To be clear, are you saying there may be some benefit from taking Longvida curcumin with Bioperine?

    3. Assuming that Longvida curcumin also undergoes glucuronidation (probably to a lesser extent than unformulated curcumin), taking Bioperine along with Longvida could feasibly increase the bioavailability further.

      Glucuronidation is part of the phase II detoxification system in the liver, responsible for eliminating a wide variety of substances (some of which are pollutants, for example PCBs), so there may be mixed effects of inhibiting this process.

  8. I also read on some blog (don't remember where exactly) that bioavailability of curcumin was 1,7x fold better if slightly heated. The user of the blog who apparently did a lot of research said she consumes it with heated full fat milk and I think omega 3. Also she had an idea that it is better to consume larger dose all at once instead of dividing it in multiple doses throughout the day. Any thoughts ? I will try to find the links or maybe some journals on that matter