Found this on another site. In light of earlier observations about quercetin, maybe some reevaluation is warranted. Thoughts Stephen
Here is what I have found out about the Temodar resistance of MGMT unmethylated:
"Our results demonstrated that U87/TR was MGMT negative, which indicated
that MGMT made no contribution for TMZ-resistance of U87/TR.
It indicated that activation of Akt and Wnt/β-catenin pathways may be
response for the chemo-resistance and increased invasion of U87/TR
cells, and the phosphorylation of PRAS40 and inactivated mTOR may be
related to cell cycle arrest in U87/TR cells."
And here they see that Quercetin could reverse that:
The cell survival rate was less than 50% in U87/TMZ group that was
pretreated by quercetin combined with TMZ at the concentration of 50
μmol·L-1.Conclusion The drug-resistant U87/TR cell line was
established. Combination of quercetin with TMZ could reverse drug
resistance of U87/TR cells. It suggests that quercetin combined with TMZ
maybe enhances chemotherapeutic effect on glioma.