Saturday, 27 August 2016

Intranasal delivery

This post is a response to Joanne's post about the cerebellum, as I wanted to include a visual.  For tumors in the cerebellum, the method of delivery might be the most important factor.  According to one study,

"The cerebellar uptake of IN delivered neurotherapeutics is found to peak at 12h rapidly declining by 24h. IP delivery does not exhibit peak cerebellar uptake at any particular time point, rather it is observed to be at the same level at all time-points. Cerebellar uptake of neurotherapeutics after IN delivery is ~5 ± 2 times greater than that after IP delivery"

In other words intranasal delivery results in far higher drug levels in the cerebellum compared to intraperitoneal injection, which is the usual method for delivering drugs to lab animals.

Click on image above to enlarge.  The 4 lines at the top represent levels of therapuetics (including curcumin) in the cerebellum after intranasal delivery.  The 4 flat lines on the bottom are the same therapies after intraperitoneal injection to mice.  Quite an impressive difference.

The question from here is which therapies are formulated for intranasal delivery.  Perillyl alcohol and chlorotoxin (scorpion venom) are taken this way, though neither of them are easy to access.  As we've discussed recently there are curcumin nasal sprays on the market, though I haven't seen any clinical research published with them.

Let's make this the "intranasal therapy" thread.


  1. Stephen,
    Do you think this would be the same as the Curecumin nasal spray by bioponic?

    1. This product is a turmeric spray. Turmeric isn't the same thing as curcumin. Curcuminoids (predominately curcumin) make up only 2-6% of turmeric by weight.

      For that matter, the Bioponic product may be just turmeric as well (as opposed to the extracted curcuminoids). There is no label with the curcuminoid content of this product as far as I can see. I'm not sure I would be willing to spend much money on any curcumin or turmeric product without a verified curcuminoid content shown on the label.

  2. This sounds like something promising but still I couldn't find human studies