Sunday 28 August 2016

Optimising cancer immunotherapy

Interesting information on immunotherapy

http://emjreviews.com/wp-content/uploads/Optimising-Cancer-Immunotherapy-Challenges-and-Opportunities.pdf

5 comments:

  1. Very interesting information for all of us. Checkpoint inhibitors modulate an immune response. So if there is no immune response, they will not function. Sometimes people forget that.

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    1. It would be interesting to speculate that the minority of recurrent GBM patients that have responded to PD-1 inhibition alone in the preliminary trials might have been hypermutated, which studies in other cancers show is predictive for response to these PD-1 antibodies.

      Hypermutation = more neoantigens for the immune system to recognize as non-self

      http://www.nejm.org/doi/full/10.1056/NEJMoa1500596#t=article
      "PD-1 Blockade in Tumors with Mismatch-Repair Deficiency"

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  2. Very interesting, thank you for sharing.

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  3. https://www.sciencedaily.com/releases/2016/12/161201164457.htm

    "An existing drug known as a JAK inhibitor may help patients who don't respond to the so-called checkpoint inhibitor immunotherapy drugs overcome that resistance, suggests a new preclinical study. Importantly, the results demonstrate that shutting down the interferon pathway, shown here to be critical to a tumor's resistance to immunotherapy, with a JAK inhibitor may improve checkpoint inhibitor drugs and even bypass the need for combinations of these drugs, which often come with serious side effects."

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  4. Interesting, though insurance companies are very unlikely to approve ruxolitinib for GBM, and cost in the US for a 28 day course is about $7000-$9000.

    On the other hand, consider propranolol, a cheap off-patent drug that could cost as little as $15 per month. Improves response to tumor lysate vaccines in mouse models.

    https://www.ncbi.nlm.nih.gov/pubmed/27899275

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