My father is due on Tuesday for the first follow-up after radiation and two rounds of monthly 5/23 high dose TMZ.
No MRI was taken after radiation but prior to monthly TMZ. I asked the NO if it wouldn't be a good idea to have an MRI taken one month after the RT, but she said it was too early to see the effects of the radiation, and besides it simply wasn't their way of doing things.
So this will be the first MRI to compare to the post-op scan taken the day after surgical resection of the tumors.
Since he's MGMT unmethylated I suspect the TMZ will not have had that much of an effect, and thus the question: What to do if the scan shows progression or recurrence?
Continue the monthly TMZ or suggest something else - carboplatin, irinotecan, re-operation if possible, try the german clinics, something else?
I guess CCNU wouldn't really be any better, since it works the same way as TMZ?
What would be the least bad/unpromising "salvage therapy" - Stephen?
I had a quick check on clinical trials in Sweden but nothing targeting recurrent tumors.
* EGFR positive/staining (but unknown if EGFRvIII mutated or not)
* IDH1 R132 negative/unmutated.
* Weak p53 staining (likely unmutated p53)
* No loss of 1p or 19q.
* MGMT unmethylated (9% methylation)