Wednesday 20 January 2016

Drug sensitivity testing?

I am wondering if doing tumor sensitivity testing would be beneficial for glioblastoma. I am wondering if anybody on the blog has done any drug sensitivity testing of the tumor tissue . What things to test for and if test at all. Does the test include vit d response testing or testing for estrogen receptors to check if tamoxifen would work. etc. There reason I am asking is since there is a BBB would it make sense to test since some of the drugs would not cross the bbb anyway.
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6 comments:

  1. Stephen W20 January 2016 at 17:50

    Was the tumor frozen? If so, it probably can't be used for chemosensitivity testing (but still can be used for genetic testing and making a vaccine).

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  2. lucy20 January 2016 at 21:16

    The tumor was preserved alive despite the fact that arrived after 5 days. They said that yes we can still do chemo-sensitivity test on it. So the question now is does it make sense to do that chemo sensitivity testing does it add much value? Should we order something like vit d test, or estrogen receptor testing to check if tamoxifen would work? Any other suggestions?

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  3. SanJuan Dave21 January 2016 at 13:29

    I believe there is some sort of startup called Notablelabs that had the idea of testing drugs on tumor samples. I may be wrong and Stephen W would know more, if there is anything to it.

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    Replies
    1. Stephen W21 January 2016 at 18:09

      This is true. If anyone would like more info on Notable, please email me.

      Delete
  4. Stephen W21 January 2016 at 18:27

    There is also a trial at Swedish in Seattle, testing a similar process.

    https://www.clinicaltrials.gov/ct2/show/NCT02654964

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  5. Anonymous21 February 2016 at 16:31

    Not worth testing since the drugs can't cross the BBB.

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