I wanted to provide an update and ask a question. Overall Dad has been doing much better since starting Avastin in November. Within weeks he regained strength in his right side (tumor is left) and after a month or so was able to transfer himself in/out of his bed and wheelchair. This was huge. His right hand went from not working at all to being able to clench into a fist at I would say 90% of his previous strength. So overall, very happy with our progress on the cocktail.
Now for my question. This week Dad seems to be a little worse for wear. More aphasia than before and needing help getting into/out of bed and his chair. He's very constipated - I think it's been 5 or maybe 6 days. We give him milk of magnesia, stool softener, miralax and enemas daily. Just not kicking in I guess. Could the constipation be the source of his mini-decline? Should we reintroduce dexamethasone? We had tapered off completely around Christmas. Was on 16mg per day, tapering 2mg per week for several weeks. Any other considerations?