To those of you battling with recurrent GBM (or grade 3 tumors): Are you being treated with Avastin alone or Avastin plus chemo?
My wife is being treated with Avastin + lomustine (CCNU). Yet I have just seen that a recently completed phase 3 study concludes that combining Avastin and CCNU does not improve survival. http://www.cancernetwork.com/sno-2015/lomustine-bevacizumab-fails-improve-survival-recurrent-glioblastoma The prior phase 2 study indicated prolonged PFS for MGMT methylated patients receiving the combination, but the 9 months overall survival was precisely the same (67 %) for MGMT methylated patient receiving the combination vs. those receiving Avastin alone.
The obvious question is: Is it worthwhile enduring the extra toxicity events that the chemo causes when it is so questionable if anything is gained by it?
Would it not be better to stick to Avastin alone (and combine it with DCA, Chloroquine, CBD, and Honokiol, as recommended by Stepehen)?