Thursday, 4 February 2016

Wife's Cocktail

Hello, everyone.
My 36 YO wife was diagnosed with a GBM on 11/12/2015, just four days after giving birth to our first child, debulked of 60-80% on 12/15/2015 and had the Gold Standard from 1/5/2016-1/25/2016. We have been on a ketogenic diet since 1/8/2016. She is MGMT methylated

This is what my wife was/is taking so I wanted to know everyone's thoughts if they had any:

During Radiation/Chemo
  • Zofran - 4mg/3X/day
  • Dexa - 4mg/2X/day
  • Temodar - 110mg/1X/day
  • Valcyte - 450mg/4X/daily
  • Keppra - 1000mg/2X day
  • Celebrex - 200mg/1X/day
  • Depakote - 250mg/3X/day
  • Nexium - 20mg/2X/day
  • Cannibis - 10-50mg/day as needed
  • Mushroom extract (Matake) - 600mg/day
  • Fish Oil - 1100 mg of EPA plus 120 mg of DHA (2X/day) (2 capsules)
  • Super Bio Curcumin/Turmeric - 400mg/2X/day
  • Multivitamin


After 1/25/2016 to today
  • Dexa - 4mg/morning - 2mg/night
  • Valcyte - 450mg/2X/daily
  • Keppra - 1000mg/2X day
  • Celebrex - 200mg/1X/day (finishing 1/19/2016)
  • Depakote - 250mg/3X/day
  • Nexium - 20mg/2X/day  (finishing 1/19/2016)
  • Cannibis - 100-250mg/day as needed
  • Mushroom extract (Matake) - 750mg/day
  • Fish Oil - 2200 mg of EPA plus 240 mg of DHA (2X/day) (4 capsules)
  • Super Bio Curcumin/Turmeric - 400mg/3X/day
  • Brocolli sprout extract - 1000mg/2X/day (concerned about antioxidating effects)
  • Green Tea - 1-2 cup/day
  • ECGC - 400mg/1X/day (concerned about antioxidating effects)
  • Pomegrante Extract  - 500mg/1X/Day (concerned about antioxidating effects)
  • Vitamin D - 2000 IU/1X/day- potentially more (1 capsule)
  • Multivitamin
Questions
She is getting pill fatigue so I'm wondering what I can do to reduce/add pills for the most impact:
  1. Should we increase the antioxidants (ECGC, Pomegranate, VitaminD, and Broccoli Sprout Extract)?
  2. We have DCA - is there a risk if we do that in addition to the ketogenic diet?
  3. We anticipate having access to chloroquine in 20 days, is it too late to add that?
  4. As a followup to the last question, the reason why we didn't add the chloroquine is that it's contra-indicated for Celebrex, which we felt was more important.
  5. What is considered a "low-dose" of Celebrex?
  6. Any other suggestions?


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4 comments:

  1. Stephen W5 February 2016 at 21:37

    Hi Logan,

    Regarding the supposed contra-indication between chloroquine and celebrex, please see the prior post and discussion from this blog. My views on this have not changed since then.


    http://btcocktails.blogspot.com/2015/09/chloroquine-and-celebrex-interactions.html

    Research done at the University of Florida has shown the combination of curcumin, EGCG, and sulphoraphane (from broccoli sprouts) could work synergistically.

    http://neuro-oncology.oxfordjournals.org/content/16/suppl_5/v82.2.short?rss=1

    As a repurposed cancer treatment, I would call 200 mg of celebrex a low dose and 200 mg twice daily a medium dose.

    ReplyDelete
    Replies
    1. Logan Lo6 February 2016 at 08:55

      Stephen, thanks for the response and detailed information (as always!)

      Delete
  2. Anonymous21 February 2016 at 16:21

    Less evidence supports the anti-oxidants, of your combination the anti-inflammatories (Curcumin etc.,) and CBD/THC have the best supportive evidence. The anit-oxidants could interfere with Temodar. Be careful of side-effects related to DCA, neropathy

    ReplyDelete
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