Monday, 22 February 2016

Dosage for Cannabis spray/oils

I continue to get different feedback on the dosage for cbd-thc (1-1 ratio) spray or oil. I am currently giving my husband 3 sprays per dose, 5 doses a day. Greg has been taking about 180mg per day since June 1, 2015. This dose was recommended by Dr. Allan Frankel, a former UCLA internist and now a medical marijuana doc in Santa Monica, California (http://www.greenbridgemed.com/).  Other sites recommend as much as 700-1000mg of combined cbd and thc. That amount, 700-1000mg seems like a lot and it costs about $1,100 per month vs, $200 a month which is the amount we spend now.  I know that money shouldn't be a factor but before we invest in this level of spending I want to make sure it is the right thing to do. Any thoughts? 

10 comments:

  1. Hi AGM,

    I have also been baffled by this dosage. I imagine it would be incredibly strong let alone as you say super expensive. Mum takes Aunt Zeldas CBD oil which is roughly 21:1 CBD:THC and they recommend a maximum of about 150mg of that a day (split into 2 doses, 75mgx2) for what Mum is using it for. She had been taking 200mg/day but Aunt Zeldas made a point to say that sometimes less is more. They also recommend taking THC alongside it too but as we have not done that yet I am not sure how much of a dosage of THC they recommend.

    I would also be curious to hear what others are using and at what dosages.

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    1. Aunt Zelda's recommended 125mg of both THC and CBD per day for us (equal to 200mg of THC-high and CBD-high oil per day, divided in two doses), although my wife can't take that much THC. She's taking ~30mg before bed and even that makes her uncomfortable if she wakes up during the night.

      A monthly cost of this regimen is about $600.

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    2. Perhaps it would be easier for her to take it if it's broken out to five doses instead of two. Two seems like a lot to take and our MD recommended spreading it out over the course of the day. $800 sounds like a lot of money. Try Care by Design, another good product that also has 1-1 cbd-thc.

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  2. A fellow GBM friend of mine took 12.5mg of 1:1 (daily) along with the Novocure for 4 months. The tumor seemingly grew to over 4cm. She had it taken out and the pathology came back with NO ACTIVE CANCER CELLS!?! Maybe less is more.

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    1. That is so interesting to hear and great news! My Mum's pathology report from her last operation in December, after she had been taking CBD oil came back the same! The surgeon could not see any 'brown' live tissue during the operation either, he said it looked grey. Pathology results during and after operation confirmed this.
      Hard to know for sure the reason for this necrosis, but interesting to hear indeed!

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    2. That's wonderful news, let's hope Greg has equally good news tomorrow after his MRI.

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  3. The Sativex trial has a dosing scheme that might be helpful. Essentially they escalate the dose of THC/CBD in 2.5 mg increments until a maximum dose of 30 mg per day. I have not seen more than 30 of THC used, but i have seen up to 200 mg of CBD in older trials. I'm not sure there is much benefit to that quantity. The greatest benefits in preclinical studies used these with radiotherapy or chemotherapy.

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  4. Aunt Zelda's originally prescribed 300mg THC :100mg CBD for my mom and there is no way she can get up there. It is all indica type high and makes her comatose for 24 hours. Not really quality of life. At some points she was so stoned she couldn't even eat or get up to pee- 18 hours after taking the dose. The representative has been reluctant to go too far down but at most my mom can take is 90mg at night THC. I have stopped CBD because that is supposed to be during the daytime and it makes her so sleepy. I asked if they have Sativa type high CBD and she said no, only ACDC strain. They also have an oil that has THC-A, which is un-heated and research supports it is anti-inflammatory. Un-heated THC-A is not supposed to have psychoactive effects. I am still cautious and give it only at night.

    They also said that Care By Design was "decent" but "Charlotte's Web" was no good.

    That's our experience anyway. I think it is very individual and changes by the product. Developing a tolerance is also a factor to consider....

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  5. Has anyone tried making their own oil? Other than lab testing I don't know how you would obtain the CBD:THC ratio that is desired, but the process of making the oil seems simple enough.

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  6. Aunt Zelda's is a good resource. We have used them. I like that their products are lab tested and pesticide free. For $200, you can consult with their doctor by phone regarding your specific history before they decide the best % of THC/CBD oil. Their prices are high however.
    Another very good resource with better price is:
    https://myriamshope.org/
    I really like the owner because she started this group because her Mother, Myriam, passed away from GBM so her heart is really in it. She has helped a lot of people with GBM. I had a very lengthy conversation with her. We will use her when our supply runs out. She has written some really good articles for this group where you will find a lot of good information if you search "brain cancer" on http://www.unitedpatientsgroup.com/
    Candy

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