I take fluoxetine daily and ondanzetron for about 10 days during and after TMZ. I have not had any issues.Mike B
Thank you very much it was just something that I have read http://www.drugs.com/interactions-check.php?drug_list=2758-0,593-0,757-0,810-0,865-0,940-0,1015-0,1433-0,1548-0,1573-0,1612-0,1750-0,1752-0,917-482,560-284,2128-12875,1448-858,1015-567,1115-648,2154-1403,2061-1352
My husband has taken fluoxitine at 20mg a day for a year, and he also took ondansetron during radiation and while on TMZ cycles, and did not have any problemsJaki.
There are sometimes "false alarms" in the drug databases, and this may be one of them. A psychiatrist told me he has not had problems with this particular combination.
Hi all thank you very much for you help
1. My mom takes 40 mg of fluoxetine and 8 mg of ondansetron in the days of temozolomide. So far there are no side effects.2. Controversial information about the role of serotonin in tumors in this new article: https://www.ncbi.nlm.nih.gov/pubmed/29936294http://sci-hub.tw/https://doi.org/10.1016/j.biochi.2018.06.016"Several data are also available on serotonin involvement in cancer cell migration, metastatic dissemination and tumor angiogenesis. The serotonininduced signaling pathways that promote tumor progression are complex and only partly understood in some cancer types. The results of several studies showed that serotonin levels in the tumor played a crucial role in cancer progression......The incidence of depression is greatly enhanced in patients with cancer and there is a debate about whether antidepressant medications must be avoided or are safe in patients with cancer [30, 31]. Indeed, SSRI, the most commonly prescribed drugs for treating depression, elevates the serotonin levels in the synaptic cleft by blocking serotonin re-uptake. As a side effect, higher levels of serotonin that result from SSRI antidepressant medication treatment could contribute to the growth of tumors. Interestingly, genetic variations in the SLC6A4 gene, which codes for the SERT, seem to contribute to poor survival in colorectal cancer patients . In contrast, fluoxetine, and a range of SSRIs, are known to have antiproliferative and cytotoxic effects at high concentrations in several cancer cells. Thus, the secondary mechanisms of action associated with these drugs began to be studied to repurposing them as first-line anticancer drugs or to combine them with standard chemotherapies ."