Saturday, 1 August 2015

Mebendazole as an anti-cancer agent

Dear all,

I am wondering if someone here is taking mebendazole?

http://www.ncbi.nlm.nih.gov/pubmed/25594199

There is some preclinical data and also a clinical study ongoing...

https://clinicaltrials.gov/ct2/show/NCT01729260?term=Mebendazole&rank=1

Best,
Katja

7 comments:

  1. Mebendazole has looked reasonably effective in several brain tumor mouse models. However mice and humans may have very different metabolism of the drug. In humans, very high doses of mebendazole are likely required to achieve therapeutic concentrations in the plasma. Doses on the order of 100mg/kg/day (a mega-dose) might be required to get enough of the unmetabolized drug in the bloodstream to see any therapeutic benefit. The safety of taking such a high dose in the context of a cocktail with multiple other drugs is unknown.

    http://www.ncbi.nlm.nih.gov/pubmed/7094986

    This paper shows that mebendazole is extensively metabolized in humans with very little unmetabolized drug making it into the bloodstream, even after high doses. I will add this paper to the pharmacokinetics folder of the Brain Tumor Library.

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  2. I could be wrong about mebendazole, but it's not near the top of my list due to its sub-optimal pharmacokinetic profile. On the other hand, it is extremely well-tolerated (probably due to its low bioavailability).

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  3. And finally, I would not add it to a cocktail at the mega-dose referenced above, but start much lower. The high plasma protein binding of mebendazole means that taking it with other drugs with high plasma protein binding could lead to higher levels of free drug in the bloodstream. This could potentially increase both the efficacy of mebendazole, as well as the risk for adverse side-effects.

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  4. Hi Stephen,
    I see you point regarding the bioavailability. We'll see if the clinical studies will show any benefit. There are couple of positive case reports, but not with gliomas.

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096024/#ref19

    Best,
    Katja

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  5. My dad uses 200 mg a day, he started today !

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  6. As Chemo/Radio did not work for my GBM4, will be adding membendazole to a list following my second resction next week. It not at the top of my list, but 'worth a punt' in my mind. Favoured by the slightly infamous London Care Oncology Clinic IRRC.

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