I am starting to consider what meds/supplements to continue Jeremy on once his TMZ is finished. Can you think of any reason to keep him on sertraline or chloroquine, from a repurposed drug point of view?
I would not put a high priority on continuing chloroquine after TMZ is finished, for reasons we've already discussed (regarding mutant p53 and autophagy), though it's conceivable that chloroquine could be synergistic with other ingredients in the cocktail.
Sertraline could be useful as an inhibitor of drug efflux pumps to help other cocktail ingredients cross the BBB.
I would not put a high priority on continuing chloroquine after TMZ is finished, for reasons we've already discussed (regarding mutant p53 and autophagy), though it's conceivable that chloroquine could be synergistic with other ingredients in the cocktail.
ReplyDeleteSertraline could be useful as an inhibitor of drug efflux pumps to help other cocktail ingredients cross the BBB.