Trivalent CAR T-cells

This study, called Trivalent CAR T-cells Overcome Interpatient Antigenic Variability in Glioblastoma, just appeared as an accepted manuscript in Neuro-Oncology.  See abstract here.

This was a preclinical study tested in mice, but is an exciting development, as this CAR T-cell cocktail approach is more likely to be effective than CAR T-cells targeted to a single antigen.

I'll upload the full study to the Library (Immunology and Immunotherapy folder, in a new CAR T-cell subfolder).

Primer on CAR T-cell therapy for GBM

This is a useful overview of CAR (chimeric antigen receptor) T-cell therapy and its application to GBM published a few days ago at CancerCommons, written by their chief scientist.

Reengineering Immune System Cells to Fight Glioblastoma (click on link)

CAR T-CELL THERAPY TO FIGHT TUMORS

Very interesting and I agree is a potentially productive treatment against GBM.

http://www.cityofhope.org/brain-cancer-2016-using-car-t-cell-therapy-to-fight-tumors