A new cocktail hypothesis

Blocking epithelial-to-mesenchymal transition in glioblastoma with a sextet of repurposed drugs: the EIS regimen. link to the study here

This is a sibling of CUSP9, as it has the same parents (Richard Kast, Marc-Eric Halatsch and company)

CUSp9

Dear all,
We just came back from the second visit from IOZK with a list of CUSP9 drugs:
1.valdoxan
2. naproxen
3. antabuse
4. minocyclin
5. propranolol
6.spironolacton
7. Valproic acid

The only one that seems to be available over the counter is naproxen as Alive. I saw also antabuse on-line at Canadian pharmacy, but the rest are definitely prescription in the US. Does anyone have any experience getting these? Thanks!

CUSP9 without being in a trial

I have asked my daughters NO to prescribe the drugs used in the CUSP9 'Concept of Treatment Trial', he has agreed to try to get them prescribed  minus the Auranofin.

He has agreed this as they can't offer anything else. Her recurrence is diffuse in cerebellum, extends to the brain stem and shows small area of enhancement round original site of left temporal lobe.
 He said Gamma knife not an option, no trials available and she is not fit to fly for magnetic or any other therapy due to lack of mobility, tiredness etc.

At present I am trying to get health insurance co to pay for Avastin, which they are saying isn't licenced in UK.

My concern is,  that apart from twice weekly blood tests I am going to have to try to oversee her treatment with these drugs and I'm very nervous. But there doesn't seem to be an alternative.

NO has said to stop Valproic Acid, presumably because of interaction.

Any thoughts gratefully received.

Cusp9?

Anyone know when CUSP9 is going to start?

CUSP-ND and Prozac

Stephen, I recently re-read the paper on CUSP-ND at:

http://www.anticanceralliance.com/cusp-nd/

and am a bit concerned at all of the "severe" interactions between Prozac and all of the other drugs in the cocktail (starting on page 104). Particularly it's interaction with celebrex and chloroquine.

My questions are:

1. If you had to choose between prozac and chloroquine, which would you choose? 
2. Moreover, I note that in Kast's CUSP9, he utilizes Zoloft (Sertraline) instead. Was there a reason that the CUSP-ND swapped out zoloft for prozac?
3. Would one be more beneficial than the other if Optune is also utilized along with the protocols?

CUSP9v3 trial start date: May 2016

Found the trial today on clinicaltrials.gov

A Proof of Concept Clinical Trial Assessing the Safety of the Coordinated Undermining of Survival Paths by 9 Repurposed Drugs Combined With Metronomic Temozolomide (CUSP9v3 Treatment Protocol) for Recurrent Glioblastoma

CUSP9v4 details uploaded

I've been conversing with Dr. Richard Kast, who helped devise the CUSP9 protocol.

He sent me details about version 4 (CUSP9v4 - 2016.03.23) and I've uploaded the file to the shared drive for your review. If you, or anyone you know, has started the protocol, can you let me/us know what you think of it and how it's working for you?

Request for information on CUSP9v3

Hello to everybody!

First of all I want to say thank you to Stephen for accepting me on this blog, It is a very helpful source of information and I deeply hope to find a right way to cover for my sister.

Here you can find a brief clinical story of Lorena:
 https://drive.google.com/file/d/0B0UTvidNw_AwOVQ4eXFVUVIyTWM/view?usp=sharing

Within few days she will undergo a magnetic resonance, to confirm or to retract the result of the previous MRI done on January. The medical result has shown the presence of an extended edema and other distinguish hallmark of glioblastoma. But Dr. Milanesi, her radiotherapist, supports the possibility that the edema may ensue from the toxicity of the CyberKnife procedure undergone in November.

Today we succeed in getting in contact with Dr. Marc Eric Halatsch who suggests to treat Lorena the use of CUSP9v3 therapy which can be administered by any licensed physician.

Do someone have undergone on this kind of procedure?
Thank you in advance
 Simone

Other Cocktail Trials?

Anyone aware of trials in the works? Also, anyone hear how cusp9 is going? I do a search every week or so but can't really find any leaks.

Grace and peace my friends,

Danny

cusp 9 protocol,

Hi all, 1....artesunate 50 mg p.o. twice daily 2....aprepitant 80 mg p.o. twice daily 3....sertraline 50 mg p.o. twice daily 4....captopril 50 mg p.o. twice daily 5....auranofin 3 mg p.o. twice daily 6....nelfinavir 1250 mg p.o. twice daily 7....temozolomide 25 mg/M 2 p.o. twice daily 8....disulfiram 250 mg p.o. twice daily 9....copper (cupric) gluconate 2 mg p.o. twice daily 10...ketoconazole 200 mg p.o. twice daily This was the original CUSP9 version (2013). They are now on version 3. ritonavir replaces nelfinavir celecoxib is in, copper gluconate is out itraconazole replaces ketoconazole minocycline is in, artesunate is out The third CUSP9 paper should be published fairly soon. Stephen, we could use this info? Melinda.

Disulfiram and copper

Steven

Do you know what dose of copper would be used with disulfiram?  Being copper seems to be involved in cancer growth if not initation, it seems that the lowest dose of copper should be used.

Also, I am of the belief that it is the copper that is beneficial, not the gluconate component (the study specified CU gluconate)  Typically we see various chelated forms of minerals have different bioavailabitly, but it is the mineral with the therapeutic effect.  In the disulfiram/copper combination I suspect this is the case as well.  Do you know if there is something special about this particular copper preparation that gives it synergy with disulfiram?

Sertraline vs Fluoxetine

Steven and others…

I have been considering switching from Sertraline to Prozac.  I would appreciate your thoughts:   

Heres what I know based on what Steven has written on his web site.

·           

• When sertraline was added to doxorubicin it resulted in increased chemosensitive over fluoxetine and doxorubicin.  This is apparently due to sertraline’s ability to impact efflux pumps better than fluoxetine.  I do not know if TMZ and doxorubicin are comparable with regards to benefits brought about by inhibiting efflux pumps.

•    Prozac inhibits MGMT activity, sertraline does not

•     Disulfiram inhibits MGMT activity

Then from CUSP9*:

•  Sertraline blocks multiple survival pathways.  No mention of this is made with fluoxetine

So here are my questions:

• If sertraline inhibits efflux pumps as does disulfiram, how important are PPI’s likely to be if both sertraline and disulfiram are already being utilized?

• Since disulfiram already inhibits MGMT activity, in theory fluoxetine would not need to be used for this (ignoring the possibility of synergy for now).  And since both sertraline and fluoxetine inhibit efflux pumps, it seems sertraline might be better combined with disulfiram rather than fluoxetine and disulfiram because sertraline has the added benefit of blocking multiple survival pathways.  Do you agree with my thinking on this?

• Fluoxetine does inhibit MGMT as does disulfiram and I suspect the synergy between the two could be beneficial, but since we are dealing with an IDH1 mutation, presumably most of the cells are MGMT methylated.  There would of course be other cells that are not methylated that could benefit from MGMT inhibition, but with disulfiram in the mix already, do I need to prioritize fluoxetine over sertraline because of this?  Or would the added benefit of blocking survival pathways be of more importance?  I realize there is no known answer to this and I am asking you to offer input lacking any data, but I am wondering if based on what you have read, this makes sense.

• Jeremy is not willing to add a PDE5 inhibitor to his cocktail.  I think he has had his fill of drugs and supplements.  Does sertraline seem to improve BBB penetration? 

Thanks for the input!