Today we made the first dropper of curcumin. 150 mg of curcumin with 250ml of 0.9NaCl. The dropper lasted 2 hours. On this day, the dose of oral curcumin was 5x400 mg (Longvida, SLCP).
There are several reports of possible synergies between curcumin and temozolomide. Does it follow from these studies that a drip of curcumin, oral curcumin and temozolomide should be taken in such a schedule so that their concentrations in the blood are maximized at the same time?
2014 https://www.ncbi.nlm.nih.gov/pubmed/25050915
We demonstrated that CUM enhanced the therapeutic response to TMZ in U87MG glioblastoma by enhancing apoptosis... We demonstrated that CUM enhanced the therapeutic response to TMZ in U87MG glioblastoma by enhancing apoptosis.
2015 https://www.ncbi.nlm.nih.gov/pubmed/26239619
Combined curcumin and TMZ treatment significantly (P<0.05) inhibited U‑87 MG cell proliferation and induced apoptotic death, compared with each alone.
2015 https://www.ncbi.nlm.nih.gov/pubmed/25542083
Autophagy inhibition improves the efficacy of curcumin/temozolomide combination therapy in glioblastomas.
Soon we will have 5 days of temozolomide. I think about whether it will be useful if temozolomide is taken at the beginning of a 2-hour dropper of curcumin?
There are several reports of possible synergies between curcumin and temozolomide. Does it follow from these studies that a drip of curcumin, oral curcumin and temozolomide should be taken in such a schedule so that their concentrations in the blood are maximized at the same time?
2014 https://www.ncbi.nlm.nih.gov/pubmed/25050915
We demonstrated that CUM enhanced the therapeutic response to TMZ in U87MG glioblastoma by enhancing apoptosis... We demonstrated that CUM enhanced the therapeutic response to TMZ in U87MG glioblastoma by enhancing apoptosis.
2015 https://www.ncbi.nlm.nih.gov/pubmed/26239619
Combined curcumin and TMZ treatment significantly (P<0.05) inhibited U‑87 MG cell proliferation and induced apoptotic death, compared with each alone.
2015 https://www.ncbi.nlm.nih.gov/pubmed/25542083
Autophagy inhibition improves the efficacy of curcumin/temozolomide combination therapy in glioblastomas.
Soon we will have 5 days of temozolomide. I think about whether it will be useful if temozolomide is taken at the beginning of a 2-hour dropper of curcumin?
