Nigella sativa is a widely used medicinal plant throughout the world. Most of the therapeutic properties of this plant are due to the presence of thymoquinone which is major bioactive component of the essential oil.
There is more information about the possible intranasal use of thymoquinone for the treatment of glioblastoma.
Therapeutic Potential of Thymoquinone in Glioblastoma Treatment: Targeting Major Gliomagenesis Signaling Pathways
2018 https://www.hindawi.com/journals/bmri/2018/4010629/
"Due to its multitargeting nature, TQ interferes in a wide range of tumorigenic processes and counteract carcinogenesis, malignant growth, invasion, migration, and angiogenesis.
Its potential to enter brain via nasal pathway due to volatile nature of TQ adds another advantage in overcoming blood-brain barrier."
"Interestingly, even the lower efficacy and poor bioavailability of TQ are the primary bottleneck of TQ, its volatile nature provides opportunity to be exploited for use in novel drug delivery strategy via intranasal pathway to brain due to unique connection provided by the olfactory and/or trigeminal nerve system present between the olfactory epithelium and the central nervous system. Such delivery system provides opportunity to bypass both the BBB and hepatic first-pass metabolism."
2012 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497894/
"The studies suggest intranasal delivery of TQ to be a promising approach for brain targeting as well as in reducing the systemic exposure."
2016 https://www.ncbi.nlm.nih.gov/pubmed/26976069
"Present work aims to prepare nanoemulsions (Thymoquinone Mucoadhesive Nanoemulsion) in order enhance the bioavailability of drug and hence evaluate the drug targeting in brain via non-invasive nasal route administration."
The question is, how can we now do inhalations with Thymoquinone to benefit from it? In what form can we use Nigella sativa / Thymoquinone for inhalations?
- Thymoquinone, ≥98,5% (GC):
https://www.sigmaaldrich.com/catalog/product/sial/03416
- Essential oil from Nigella sativa:
https://www.amazon.com/Black-Cumin-Essential-Nigella-sativa/dp/B01G8ZTX12
- Or without inhalation, just like a drop for a nose:
https://www.etsy.com/listing/565401697/black-seed-nose-drops-nigella
And additionally about the effect of oral Nigella sativa oil on metabolism:
https://www.ncbi.nlm.nih.gov/pubmed/19902033
"A RCT done on 60 patients with metabolic syndrome showed that NS oil (5 mL/day) used in combination with atorvastatin and metformin could decrease fasting blood sugar (FBS), LDL, and TC significantly after six weeks of use."
There is more information about the possible intranasal use of thymoquinone for the treatment of glioblastoma.
Therapeutic Potential of Thymoquinone in Glioblastoma Treatment: Targeting Major Gliomagenesis Signaling Pathways
2018 https://www.hindawi.com/journals/bmri/2018/4010629/
"Due to its multitargeting nature, TQ interferes in a wide range of tumorigenic processes and counteract carcinogenesis, malignant growth, invasion, migration, and angiogenesis.
Its potential to enter brain via nasal pathway due to volatile nature of TQ adds another advantage in overcoming blood-brain barrier."
"Interestingly, even the lower efficacy and poor bioavailability of TQ are the primary bottleneck of TQ, its volatile nature provides opportunity to be exploited for use in novel drug delivery strategy via intranasal pathway to brain due to unique connection provided by the olfactory and/or trigeminal nerve system present between the olfactory epithelium and the central nervous system. Such delivery system provides opportunity to bypass both the BBB and hepatic first-pass metabolism."
2012 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497894/
"The studies suggest intranasal delivery of TQ to be a promising approach for brain targeting as well as in reducing the systemic exposure."
2016 https://www.ncbi.nlm.nih.gov/pubmed/26976069
"Present work aims to prepare nanoemulsions (Thymoquinone Mucoadhesive Nanoemulsion) in order enhance the bioavailability of drug and hence evaluate the drug targeting in brain via non-invasive nasal route administration."
The question is, how can we now do inhalations with Thymoquinone to benefit from it? In what form can we use Nigella sativa / Thymoquinone for inhalations?
- Thymoquinone, ≥98,5% (GC):
https://www.sigmaaldrich.com/catalog/product/sial/03416
- Essential oil from Nigella sativa:
https://www.amazon.com/Black-Cumin-Essential-Nigella-sativa/dp/B01G8ZTX12
- Or without inhalation, just like a drop for a nose:
https://www.etsy.com/listing/565401697/black-seed-nose-drops-nigella
And additionally about the effect of oral Nigella sativa oil on metabolism:
https://www.ncbi.nlm.nih.gov/pubmed/19902033
"A RCT done on 60 patients with metabolic syndrome showed that NS oil (5 mL/day) used in combination with atorvastatin and metformin could decrease fasting blood sugar (FBS), LDL, and TC significantly after six weeks of use."
