Hi all,
Thank you so much to Stephen, Ben, and all of you folks for sharing your insights and information as we navigate through this. I had emergency surgery a few weeks ago and was diagnosed with GBM wild type. The tumor was 7 cm, right parietal lobe, full resection, MGMT methylated, IDH1 negative. My pathology report shows high CBL mutation frequency, high TP53, and my PDGFRA mutations and amplification appear frighteningly off the charts, but that's a whole other question :/
I've put together a cocktail for my six-week chemoradiation term, into which I'm eight days. I would appreciate any recommendations on what I might add, remove, revise. Thank you!
Medication
|
DailyDose
|
Temozolomide
|
100 mg
|
Celebrex
|
400 mg
|
Chloroquine
|
250 mg
|
Naltrexone
|
4.5 ml
|
Melatonin
|
20 mg
|
Noscapine*
|
60 mg
|
CBD/THC
|
1 g
|
Progesterone**
|
300 mg
|
Supplement
|
Daily Dose
|
Boswellia
|
5 g
|
Berberine
|
1 g
|
Curcumin
|
5 g
|
Flaxseed Oil
|
43 g
|
Garlic Extract
|
|
GLA
|
3 g
|
Magnesium
|
200 mg
|
Probiotics
|
|
PSP
|
3 g
|
Sulfurphane
|
120 mg
|
Milk Thistle
|
1 g
|
Zinc
|
25 mg
|
(I'm holding off on antioxidants until after radiation.)
*Noscapine: One of my doctors recommended it. I haven't seen it mentioned here, and I'm wondering if its inclusion is truly beneficial or should be removed. Here are some links:
Noscapine inhibits tumor growth in TMZ-resistant gliomas
https://www.ncbi.nlm.nih.gov/pubmed/21925789
Synergistic suppression of noscapine and conventional chemotherapeutics on human glioblastoma cell growth
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002615/
But this thesis contends it's effective on its own for glioma cells but is not synergistic with TMZ. http://digitallibrary.usc.edu/cdm/ref/collection/p15799coll127/id/269936
**Progesterone
I had already been taking this before my diagnosis, and I increased the dose after having read some promising studies.
Anti-tumor effects of progesterone in human glioblastoma multiforme: role of PI3K/Akt/mTOR signaling
https://www.ncbi.nlm.nih.gov/pubmed/24787660
Synergistic Effect of Combination Progesterone and Temozolomide on Human Glioblastoma Cells
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131441
But then I came across this:
Proliferative and Invasive Effects of Progesterone-Induced Blocking Factor in Human Glioblastoma Cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5266854/
Does the latter study imply it's instead dangerous for me to be on progesterone at all?
Thank you, and strength, peace, and healing to you all!
