Hi everyone! Thank you for your advice, guidance and experience. I wish everyone a complete recovery!
My name is Kirill, age
33. I am looking for help and advice.
Analysis results: A diffuse glioma with infiltrative growth into the brain tissue is revealed. The tumor is represented mainly by the astrocytic component, also a little oligodendrocytic and hemistocytic. Mitotic figures are noted. Cellular density is increased. Reactive endothelium is found in the vessels.
- Anaplastic astrocytoma, WHO Grade 3
- IDH1 R132 H - mutant
- MGMT - unmethylated
- Ki-67 up to 15%
I had the following treatment:
- Proton therapy course 6 weeks. Radiation quantity 60 GyE. Finished 08/25/2020. At the time, I had no information about additional treatment that you discuss on the forum, so I have not used the means for increasing the sensitivity of the tumor in radiation therapy.
- Temozolomide 200 mg/m2 (in my case 350 mg). Standard schedule 5/28.
04/23/2020 – 8 course.
During chemotherapy, I ate large amounts of antioxidant foods (broccoli, berries, green tea, garlic, onions, parsley, etc.). I have a simple diet: whole grains, refusal of meat in favor of fish, refusal of sugars and simple carbohydrates, a lot of vegetables and fruits, greens. I also took: curcumine, boswellia, omega-3, lycopene, resveratrol. Daily walking at least 1 hour.
At the moment, a fairly large cyst has formed at the place of the surgery. MRI 03/09/2021 shows stable results, no positive nor negative changes. PET/ะกT 04/02/2021 shows relapse. The doctors asked for a second MRI to check. The doctors, as usual, are conservative and treat according to the protocol.
After such news, I immediately bought medicines and dietary supplements,
which are recommended on the forum.
Medicines:
- Levetiracetam
- Fluoxetine
- Mifepristone
- Hydroxychloroquine
- Metformin
- Valaciclovir
- Disulfiram
- Minocycline
- Atorvastatin
- Mebendazole
- Tamoxifen
- DCA
- Celecoxib
I would be
grateful for your help, whether they suit me and how to combine them all.
Dietary
supplements:
- Berberine
- Fungi Perfecti, Stamets 7
- Fungi Perfecti, Host Defense Turkey Tail
- Now Foods, EGCg, green tea extract, 400 mg,
- Life Extension, optimized resveratrol
- Life Extension Boswellia serrata
- Curcumin SLCP
- Now Foods, silymarin
- Solgar, vitamin D3 5000 ME
- Now Foods, ultra omega-3
- Life Extension, Mega Lycopene
I really want the tumor to shrink. Thanks to your forum, I plan to:
- Switching to the metronomic schedule Temozolomide, dose 70-80 mg / kg2. 3 weeks taking, 1 week off. Or without interruption if I have enough strength.
- Add Levetiracetam, Fluoxetine, Disulfiram, Valproic Acid to reduce the effect of MGMT
- Add Metformin for blood glucose control.
Thank you for your opinion and advice:
- What medications can be added (or removed), in what dose and for how long should I take it?
- Is it a good idea to add Agomelatine before taking Temozolomide on a metronomic schedule?
- How do Levetiracetam and Fluoxetine interact, how and in what quantities is it better to take them together?
- What do you think about Temozolomide + Tamoxifen at this stage? I am thinking about Tamoxifen, because for a year now I have a very high level of estradiol, always the very upper limits. I heard that it could somehow relate to a tumor. I also know that Ben Williams has been taking Tamoxifen on a regular basis. I know that Tamoxifen is not very friendly with Fluoxetine...
- Please suggest a different scheme if you have different opinion.
If such a scheme does not bring the desired result, then I plan to take Lomustine.
Since I heard that Lomustine may be useful in the case of Astrocytoma-Secondary
glioblastoma independent of MGMT.
Thank you for your opinion and advice:
- Do I need to add drugs that reduce the effect of MGMT? Maybe there is a better combination of Lomustine with other drugs? Or is Lomustine not the best option / combination?
- What medications can be added (or removed), in what dose and for how long to take?
- Please suggest a different scheme if you have different opinion.
What are your thoughts on having several different short courses of chemotherapy? Ben Williams drastically changed his schemes so that cells did not have time to mutate, adapt and survive.
- Maybe TMZ + Tamoxifen
- Then BCNU (Carmustine)
- Then Procarbazine, oral Lomustine (CCNU). This regimen is known as PC
- Then TMZ + ??? or Avastin + ???
- + Dietary
supplements
- + in my case reduce the effect of unmethylated MGMT …
What combinations can fit in my case?
If there will be a second operation, what is the best way to build a
more effective treatment with the information already available?
I think there may be several options:
A) Radiation
therapy may be prescribed.
I will do the following:
1) Adjuvant therapy Temozolomide + reducing the effect of unmethylated MGMT (Levetiracetam, Fluoxetine, Valproic Acid + ???)
2) I will add drugs that will increase the tumor sensibilization to radiation therapy.
What exactly to add and in what doses in my case?
B) They may refuse the radiation therapy and prescribe chemotherapy.
What is the best way to start chemotherapy? Should I continue Temozolomide on the metronomic schedule or change something?
I have a great need to
find a specialist, an experienced person with whom there could be a personal
connection during treatment. Can you help with this, Stephen?
Also, I really want to help in the development of the project, how can I
donate?
Thank you very much for your opinion and support.
