revisiting quercetin

Found this on another site.  In light of earlier observations about quercetin, maybe some reevaluation is warranted.   Thoughts Stephen


Here is what I have found out about the Temodar resistance of MGMT unmethylated:
"Our results demonstrated that U87/TR was MGMT negative, which indicated that MGMT made no contribution for TMZ-resistance of U87/TR.
It indicated that activation of Akt and Wnt/β-catenin pathways may be response for the chemo-resistance and increased invasion of U87/TR cells, and the phosphorylation of PRAS40 and inactivated mTOR may be related to cell cycle arrest in U87/TR cells."
http://www.ncbi.nlm.nih.gov/pubmed/27423571

And here they see that Quercetin could reverse that:

The cell survival rate was less than 50% in U87/TMZ group that was pretreated by quercetin combined with TMZ at the concentration of 50 μmol·L-1.Conclusion The drug-resistant U87/TR cell line was established. Combination of quercetin with TMZ could reverse drug resistance of U87/TR cells.  It suggests that quercetin combined with TMZ maybe enhances chemotherapeutic effect on glioma.

Supplements... I need to know

My brother, 34 years old, has a recurrent AA grade III. It looks that conventional chemo treatment (Temodal for 5 mos and Temodal+Carboplatin for last 2 months) is not effective so I'm looking for additional treatments. I have been reading a lot of articles in favor of supplements and some against them but we don't have many options. The main question for me is how to find the optimal dosages or optimal combinations. Another question is where/what to buy. There are so many companies on the market so it's really hard to choose among so many labels. So I need your help.

He's on Depakine/Keppra for seizures and Vitamin D because of very big deficiency.

1.  We'd like to try Curcumin. 4g or 8g/daily? Can you recommend some manufacturers by best quality/price ratio with best adsorption? Meriva, Longvida, BCM 95 or C3?
2.  I've read that Boswellia can be a replacement for dexamethasone. Is it so?
3.  Dosage for Fish Oil/Omega 3, Selenium. Manufacturers?
4.  Quercetin? I've read that it works great with Temodal and some other article states that there is no clinical evidence that Quercetin works.

And the final question for cocktail drinkers is: did you choose supplements for your cocktail by yourself or did some doctor recommend it?