Hello!
1. There is one promising report on the treatment of TMZ+Plerixafor (+Lapatinib pulse dosing) for glioblastoma:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965258/
Plerixafor was administered subcutaneously 1 time per week for 2 years.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965258/
Plerixafor was administered subcutaneously 1 time per week for 2 years.
2. And one ongoing trial studie at phase II:
https://clinicaltrials.gov/ct2/show/study/NCT01977677?term=AMD3100+glioblastoma&rank=1
https://clinicaltrials.gov/ct2/show/study/NCT01977677?term=AMD3100+glioblastoma&rank=1
Plerixafor was administered via continuous intravenous infusion of 400 micrograms/kg/day starting one week prior to end of RT and continuing for 4 weeks.
Here are published abstratcs:
http://ascopubs.org/doi/abs/10.1200/JCO.2017.35.15_suppl.2058
http://ascopubs.org/doi/abs/10.1200/JCO.2016.34.15_suppl.2068
http://ascopubs.org/doi/abs/10.1200/JCO.2017.35.15_suppl.2058
http://ascopubs.org/doi/abs/10.1200/JCO.2016.34.15_suppl.2068
3. There are also several articles about Plerixafor:
https://www.ncbi.nlm.nih.gov/pubmed/27863376
https://www.ncbi.nlm.nih.gov/pubmed/27015814
https://www.ncbi.nlm.nih.gov/pubmed/26023083
https://www.ncbi.nlm.nih.gov/pubmed/25676691
https://www.ncbi.nlm.nih.gov/pubmed/25860928
https://www.ncbi.nlm.nih.gov/pubmed/27863376
https://www.ncbi.nlm.nih.gov/pubmed/27015814
https://www.ncbi.nlm.nih.gov/pubmed/26023083
https://www.ncbi.nlm.nih.gov/pubmed/25676691
https://www.ncbi.nlm.nih.gov/pubmed/25860928
Stephen wrote that 1 shot of Plerixafor is very expensive, but I am in Delhi (India) and here Plerixafor 24mg/1.2 ml (Celrixafor by Celon Labs) is $ 1000.
What do You think about this medication and what are the tactics of its use more effective?
What do You think about Lapatinib used in the first case, pulse dosing? If it is suitable for all types of glioblastoma? clinical research is also going on:
https://clinicaltrials.gov/show/NCT01591577
https://clinicaltrials.gov/show/NCT01591577