Hello everybody!
Thank you, Stephen, for having added me-)
My name is Tanya, I'm from Ukraine, Kiev. My husband Vadim, 46 years old, has been operated glioblastoma and 28 March 2016. Now he gets radiotherapy and temozolomide.
Please, help us in the development of a strategy for the further treatment of Vadym.
We have the results of histology and immunohistochemistry:
1.Histology.
this is a very cellular glial neoplasm consisting of pleomorphic, atypical gemistocytic astrocytes which diffusely infiltrate the cerebral cortex and subcortical white matter, forming secondary structures of Scherer. Mitotic figures, including atypical forms, are readily recognized, as well as prevascular lymphocytic infiltrates and foci of microvascular proliferation. In addition, there are large areas of confluent necrosis with early organisation and some trombotic blood vessels.
2.Immunohistochemistry:
ki-67 ( sp6)- positive tumor expression to 15 %
Bcl-2a Ab-1 (Clone 100/D5)- tumor expression weakly positive,
p53 ( clone Sp5) positive expression to 5 %/
And another part of brain (left temple)/
ki-67- positive expression to 5 %
CD 45/T200/LCA Ab-2 ( clone PD7/26/16 +2B11)- positive expression in abscess,
GFAP glial fibrillary Acidic Protein Ab-6(GFAP) positive expression.
Conclusion :
Pleomorfhic glioblastoma ( ki-67- to 15 %) with a plot of abscecc.
Our protocol:
radiation and TMZ 180 mg 1х per day.
1. Metformin 2,5 mg per day (1+0,5+1)
2.Chlorochine 250 mg х 1 per day,
3. Levetiracetam 1g х 2 per day ( he has no seasures),
4. Dexametaxone 2 mg ( we are going to replace it for boswellia)
Supplements:
1 Boswellia serrata 6 caps. per day ( 1500 mg) http://ua.iherb.com/Himalaya-Herbal-Healthcare-Boswellia-60-Veggie-Caps/3689
2. Boswellia serrata 6 caps. per day ( 600 mg) http://ua.iherb.com/Life-Extension-5-Lox-Inhibitor-with-ApresFlex-100-mg-60-Veggie-Caps/40487
3. Curcumin 2400 mg per day http://www.ourkidsasd.com/products/2510%7CEnhansa%20(enhanced%20absorption%20curcumin)-Lee%20Silsby
4. Milk Thistle 150 mg х 3 times per day http://ua.iherb.com/Jarrow-Formulas-Milk-Thistle-150-mg-200-Capsules/127
5.Maitake 3 pills х 2 times per day ( Maitake body powder 3600 mg, Maitake Fruiting Body Extract PD- Fraction 1440 mg ) http://ua.iherb.com/Grifron-Maitake-Mushroom-Wisdom-Maitake-D-Fraction-Pro-4X-120-Veggie-Tabs/17000
6. EGCg 3 capsules x 2 time per day ( 2400 mg) http://ua.iherb.com/Now-Foods-EGCg-Green-Tea-Extract-400-mg-180-Veggie-Caps/11598
7. Iron 1 capsule 25 mg per day http://ua.iherb.com/Solgar-Gentle-Iron-25-mg-180-Veggie-Caps/10625
8. DHA 500 mg per day ( we are going to increase).
My most important question is, what can i add to protocol during radiotherapy?
Are the supplements, my husband takes, permissible with radiotherapy?
I would be wery gratefull for any your comments!
I wish you all good health! Thank you and especially to Stephen!
PS. Excuse me, please, for my english....it is wooden.
Tania.
Thank you, Stephen, for having added me-)
My name is Tanya, I'm from Ukraine, Kiev. My husband Vadim, 46 years old, has been operated glioblastoma and 28 March 2016. Now he gets radiotherapy and temozolomide.
Please, help us in the development of a strategy for the further treatment of Vadym.
We have the results of histology and immunohistochemistry:
1.Histology.
this is a very cellular glial neoplasm consisting of pleomorphic, atypical gemistocytic astrocytes which diffusely infiltrate the cerebral cortex and subcortical white matter, forming secondary structures of Scherer. Mitotic figures, including atypical forms, are readily recognized, as well as prevascular lymphocytic infiltrates and foci of microvascular proliferation. In addition, there are large areas of confluent necrosis with early organisation and some trombotic blood vessels.
2.Immunohistochemistry:
ki-67 ( sp6)- positive tumor expression to 15 %
Bcl-2a Ab-1 (Clone 100/D5)- tumor expression weakly positive,
p53 ( clone Sp5) positive expression to 5 %/
And another part of brain (left temple)/
ki-67- positive expression to 5 %
CD 45/T200/LCA Ab-2 ( clone PD7/26/16 +2B11)- positive expression in abscess,
GFAP glial fibrillary Acidic Protein Ab-6(GFAP) positive expression.
Conclusion :
Pleomorfhic glioblastoma ( ki-67- to 15 %) with a plot of abscecc.
Our protocol:
radiation and TMZ 180 mg 1х per day.
1. Metformin 2,5 mg per day (1+0,5+1)
2.Chlorochine 250 mg х 1 per day,
3. Levetiracetam 1g х 2 per day ( he has no seasures),
4. Dexametaxone 2 mg ( we are going to replace it for boswellia)
Supplements:
1 Boswellia serrata 6 caps. per day ( 1500 mg) http://ua.iherb.com/Himalaya-Herbal-Healthcare-Boswellia-60-Veggie-Caps/3689
2. Boswellia serrata 6 caps. per day ( 600 mg) http://ua.iherb.com/Life-Extension-5-Lox-Inhibitor-with-ApresFlex-100-mg-60-Veggie-Caps/40487
3. Curcumin 2400 mg per day http://www.ourkidsasd.com/products/2510%7CEnhansa%20(enhanced%20absorption%20curcumin)-Lee%20Silsby
4. Milk Thistle 150 mg х 3 times per day http://ua.iherb.com/Jarrow-Formulas-Milk-Thistle-150-mg-200-Capsules/127
5.Maitake 3 pills х 2 times per day ( Maitake body powder 3600 mg, Maitake Fruiting Body Extract PD- Fraction 1440 mg ) http://ua.iherb.com/Grifron-Maitake-Mushroom-Wisdom-Maitake-D-Fraction-Pro-4X-120-Veggie-Tabs/17000
6. EGCg 3 capsules x 2 time per day ( 2400 mg) http://ua.iherb.com/Now-Foods-EGCg-Green-Tea-Extract-400-mg-180-Veggie-Caps/11598
7. Iron 1 capsule 25 mg per day http://ua.iherb.com/Solgar-Gentle-Iron-25-mg-180-Veggie-Caps/10625
8. DHA 500 mg per day ( we are going to increase).
My most important question is, what can i add to protocol during radiotherapy?
Are the supplements, my husband takes, permissible with radiotherapy?
I would be wery gratefull for any your comments!
I wish you all good health! Thank you and especially to Stephen!
PS. Excuse me, please, for my english....it is wooden.
Tania.
