Reirradiation + ketogenic diet + intermittent fasting, randomized trial

ERGO2: A prospective randomized trial of calorie restricted ketogenic diet and fasting in addition to re-irradiation for malignant glioma
https://sci-hub.tw/https://www.redjournal.org/article/S0360-3016(20)31308-0/pdf    (full PDF from sci-hub)

https://www.redjournal.org/article/S0360-3016(20)31308-0/pdf   (link to journal abstract, full PDF requires a payment)

Half the patients were randomized to re-irradiation plus standard diet (SD), the other half were randomized to re-irradiation plus ketogenic diet plus intermittent fasting (KD-IF).

• PFS6 was not significantly different between the two groups (KD-IF: 20%, SD: 16%). 
• Similarly, no difference in PFS, local PFS6 and OS was observable.
• Explorative analysis revealed that patients of the KD-IF group who had a glucose of less than the median (83.5 mg/dl) on day 6 had a significantly longer PFS and OS compared to those above the median

Fasting during chemo cycles?

Hi all,

As there is some evidence in mice studies that fasting can be beneficial during chemo cycles, both sensitizing the tumor cells and protecting the regular cells I'm wondering if anyone here has tried it?

If yes, would you be willing to share your experiences?

How long time did you fast? Did you see any direct benefits? Any negative effects? How easy was it to tolerate fasting while taking chemo?

Grateful for any feedback.

Thanks