A study that caught my attention with impressive results in vivo albeit mice. They inhibited the p-P-Selectin protein to achieve the results. I found many supplements in my research reducing P-Selectin (EGCG, Melatonin, Lipitor, Resveratrol, Boswellia, etc). What was interesting I found is all the drugs tied with P-Selectin all dealt with inflammation. Sure enough, I found diets such as the Paleo, Low Fat, and Mediterranean diets reduced P-Selectin. I also found a study that correlates P-Selectin to cholesterol levels (LDL) as well as inflammatory responses to exercise.
Impact of Edema:
Exercise and LDL correlation of P-Selectin: