Wednesday 7 October 2015

cusp 9 protocol,

Hi all, 1....artesunate 50 mg p.o. twice daily 2....aprepitant 80 mg p.o. twice daily 3....sertraline 50 mg p.o. twice daily 4....captopril 50 mg p.o. twice daily 5....auranofin 3 mg p.o. twice daily 6....nelfinavir 1250 mg p.o. twice daily 7....temozolomide 25 mg/M 2 p.o. twice daily 8....disulfiram 250 mg p.o. twice daily 9....copper (cupric) gluconate 2 mg p.o. twice daily 10...ketoconazole 200 mg p.o. twice daily This was the original CUSP9 version (2013). They are now on version 3. ritonavir replaces nelfinavir celecoxib is in, copper gluconate is out itraconazole replaces ketoconazole minocycline is in, artesunate is out The third CUSP9 paper should be published fairly soon. Stephen, we could use this info? Melinda.
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8 comments:

  1. Stephen W7 October 2015 at 12:22

    There were a few changes to these drugs and dosings in CUSP9* and v3:

    Minocycline is at 100 mg po twice daily
    Celecoxib is at 400 mg po twice daily
    Ritonavir is at 400 mg po twice daily
    Itraconazole is at 200 mg po twice daily
    Sertraline was increased to 100 mg twice daily

    Itraconazole and ritonavir especially are potent inhibitors of CYP3A4, so interactions with other drugs have to be looked at carefully before adding them to a cocktail.

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  2. Dmitriy D11 October 2015 at 02:12

    I wrote about my 48 year father (we are russian)
    We now use everolimus 10mg/day, but its interact with Ritonavir and Itraconazole, and:
    celebrex 200mg twice
    yet verapamill 320mg, but soon sertraline
    disulfiram 150 mg twice
    chloroquiene 250 mg once
    mebendazole 300 mg, four times (exists trial with avastin and irrinotecan)
    nitroxaline 150 mg, four times
    cimitidine 200 mg, twice

    metformin I excluded due PTEN mutation.

    Now we on second recurrent after second surgery. Avastin + lomustine is failed for us (weak answer), now we try avastin + irrinotecan + everolimus + coctail aproach
    Our state now is stable, we wait for MRI in november.

    I ordered artemesinin (artesunate is hard to find, I look artemisinin has metobolites that acts similar to artesunate), but here I found that it excluded in version 3 of CUSP9.
    Aprepitant also hard for me to find, I found it in Germany, but they wants recipe from europe doctor and it s also expensive to add to other expensive treats (avastin, everolimus)
    And I think about Minocycline.
    We begin to increase doses a little soon, but in days with avastin and irrinotecan I think to take lower doses due to nausea.

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  3. Dmitriy D11 October 2015 at 02:27

    Also
    curcumin longa ~ 1 g per day
    green tea extract ~ 1g per day
    salvestrol 1 per day now
    d3, c, selenium and broccoli in food every day (maybe try broccoli extract)

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    Replies
    1. Stephen W12 October 2015 at 09:11

      Dmitriy,
      Thanks for sharing your dad's story.

      If you would like to start a new post I can add you to the author list. Send me your email address to braintumourreconnaissance@gmail.com

      Artemether is probably the most likely artemisia compound to help for brain tumors. You can purchase it (and artesunate, artemisinin) from this company:

      http://hepalin.com/products.htm

      Have you considered DCA, which is a good combination with Avastin?

      http://pharma-dca.com/
      http://btcocktails.blogspot.ca/p/drug-and-supplement-sources.html

      Metformin could benefit through immune effects regardless of PTEN status.

      Do you purchase nitroxiline through Russian pharmacies? It is not so easy to find in North America.

      Best wishes,
      Stephen

      Delete
    2. Dmitriy D12 October 2015 at 10:31

      We try DCA in dose 20mg/kg/day from march to July (till our second recurrence) with full ketogenic diet which managed by our nutritionist.
      All was good 6 months (compared with gold standart chemo+radio it was only 4 months)
      But troubles with liver impels us to stop it.
      I try to start it again but than troubles with liver. So I decide to stop it. For consideration my father has hepatite B (which we treat with entecavir).
      Both DCA and keto diet was found hard for us. Late in august we stop keto diet and go to vegatable diet. Liver became better. In september we start try cocktail way.

      As for today my dad is fighting with nausea several days after irrinotecan. He skip morning dose today. Same symthoms was before after avastin+irrinotecan too. But head is stable, we noted that place near tumour resection has health appearance (before it was often red).
      I think now for Aprepitant as it enter in CUSP9. Its relatively expensive, but my father don't want to increase quantity of medical supplies due side effects.

      We have nitroxoline relatively cheap. (50 tablets x 50 mg) for ~8$ in each pharmacy.
      In Russia Tagamet is not so easy to find - I order it in Amazon.
      Aprepitant about 80$ for two capsules. Mebenzadole about 1.5$ for six 100 mg tablets. But our dose now only 20 mg/kg/day (I see it starts from 50 mg/kg/day). But I try to carefully increase doses.
      I ordered http://ru.iherb.com/Doctor-s-Best-Best-Artemisinin-100-mg-90-Veggie-Caps/7592 it s suitable?

      Delete
  4. SJ Firinne28 August 2016 at 08:16

    Why was artesunate dropped? And how is the latest CUSP9 performing? I can't find any information on it.

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    Replies
    1. Stephen W28 August 2016 at 10:06

      I believe artesunate was dropped because of side-effects.
      There have only been a few patients treated with CUSP9 in Germany outside of the trial. Those cases haven't been published yet, and the formal trial is set to start this month.
      https://clinicaltrials.gov/ct2/show/NCT02770378 (CUSP9v3)

      Delete
    2. SJ Firinne28 August 2016 at 15:43

      Ah, ok, thanks.

      Delete

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