Melatonergic system-based two-gene index is prognostic in human gliomas.
This study shows that two genes related to melatonin biosynthesis (ASMT) and metabolism (CYP1B1) is an independent prognostic factor in gliomas. This index is expressed as a ratio, and tumors with high expression of ASMT (melatonin synthesis) and low expression of CYP1B1 (which converts melatonin to a metabolite that can be excreted in the urine) tend to have better prognosis. Higher grade tumors tend to have a lower ratio (ASMT:CYP1B1).
This finding could be viewed as support for supplementing with melatonin, especially for higher grade gliomas.
Will add this study to the Library.
A more detailed summary of this study can be found at Astrocytoma Options, about three-quarters of the way down the Supplements page, in the Melatonin section.
ReplyDeletehttp://astrocytomaoptions.com/supplements/
as usual, you spoil us Steven. Thanks for the info.
ReplyDeletewhen is the best time to take melatonin while on temodar? My husband does temodar for 5 days on/23 days off. He has to eat and take all of his meds, then wait 1 hour to take zofran, then wait another hour to take 460mg of temodar. He ccan't take anything for 2 hours after temodar. We try to do melatonin 2 hours after temodar but sometimes we fall asleep before and forget to take it. Any suggestions?
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