I am impressed with the immunological effects of low-dose PDE5 inhibitors in human studies (tadalafil) and mouse studies (sildenafil). If it were me I would take daily. Particularly combined with Celebrex.
For sildenafil, I would get the 20 mg tablets (generic version for hypertension) which should be much cheaper than the name brand versions Revatio (for hypertension) and Viagra (for ED). I would take 20 mg twice daily. 25 mg twice daily is probably okay too.
For reference, standard dose of sildenafil for hypertension is 20 mg three times daily, which is a smaller but more frequent dose than the dose for ED (ie 50 mg as needed).
Also keep in mind that if you're taking strong CYP3A4 inhibitors like itraconazole, you should lower the dose of sildenafil (a CYP3A4 substrate).
I asked my husband's neuro-onc about using PDE5 and this is her response: "there are studies actually showing PDE5 inhibitors to be associated with increase risk of skin cancer, melanoma, for instance, although it's not at all clear there is an association." She said she would prescribe off-label meds, but needs more convincing. How does one work with their neuro-onc to get these drugs prescribed off-label?
I am impressed with the immunological effects of low-dose PDE5 inhibitors in human studies (tadalafil) and mouse studies (sildenafil). If it were me I would take daily. Particularly combined with Celebrex.
ReplyDeleteMy brother is taking it every day
ReplyDeleteWhat is a low dose? 25mg (sildenafil) daily?
ReplyDeleteFor sildenafil, I would get the 20 mg tablets (generic version for hypertension) which should be much cheaper than the name brand versions Revatio (for hypertension) and Viagra (for ED). I would take 20 mg twice daily. 25 mg twice daily is probably okay too.
ReplyDeleteFor reference, standard dose of sildenafil for hypertension is 20 mg three times daily, which is a smaller but more frequent dose than the dose for ED (ie 50 mg as needed).
Also keep in mind that if you're taking strong CYP3A4 inhibitors like itraconazole, you should lower the dose of sildenafil (a CYP3A4 substrate).
I asked my husband's neuro-onc about using PDE5 and this is her response: "there are studies actually showing PDE5 inhibitors to be associated with increase risk of skin cancer, melanoma, for instance, although it's not at all clear there is an association." She said she would prescribe off-label meds, but needs more convincing. How does one work with their neuro-onc to get these drugs prescribed off-label?
ReplyDelete