Thursday, 15 October 2015

What could be side effects of PD1 inhibitors+ DC vaccines.Choosing immunotherapy clinic.

I am trying to choose a clinic in Germany. Some of them use only PD1 inhibitors in combination with DC Vaccines and others use DC vaccines with tetanus booster etc.
I am wondering what would be pros or cons of one versus another. Debating if to go for expensive PD1 inhibitor and peptide vaccine with unknown side effects or tetnus booster and peptide vaccine. Some of those clinics use 2 checkpoint inhibitors at once plus peptide vaccine. The side effects on nivo site seem scary. On the other hand tetanus booster plus cmv did not have any.

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9 comments:

  1. Stephen W15 October 2015 at 14:33

    Here is something interesting: Stefan van Gool has joined IOZK (September 2015).

    http://www.iozk.de/en/updates/news

    I've heard of other clinics using DC vaccines plus PD-1 and low dose CTLA-4 antibodies for brain tumor patients (such as Professor Slavin in Israel).

    I think you would be in good hands at IOZK, although I have not had a chance to read all the material at their website yet.

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  2. Aunt Jo19 October 2015 at 08:27

    What does all this mean?

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  3. Stephen W19 October 2015 at 10:54

    Anna is researching several German clinics that offer immunotherapy with dendritic cell (DC) vaccines in combination with other agents that enhance immune responses such as PD-1 antibodies (nivolumab/Opdivo and pembrolizumab/Keytruda). IOZK is one of the clinics in Germany that offers these therapies.

    I'm not aware of any clinic offering DC vaccines outside of clinical trials in the USA, and the PD-1 inhibitors are very expensive, although there are many clinical trials testing these drugs for GBM.

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  4. Unknown20 October 2015 at 19:34

    We are planning to travel to get some NVD+DC combinated teraphy in Duderstadt once my wife fully recovered. Yesterday had her 3rd surgery due to a massive cyst (orange size...the big ones). Fortunatedly we have some tumor tissue stored to improve our odds. Looking forward to be there as soon as possible.

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  5. Unknown5 November 2015 at 03:59

    Hi, does anyone have any experience with either IOZK or Duderstadt? Any other clinic that should be considered for DC Vaccine + PD-1?

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    1. Stephen W5 November 2015 at 08:41

      Guy, and everyone. I've created a table in the Library, which attempts to organize the pertinent information about Duderstadt, IOZK, Unifontis and Hallwang clinics in Germany. This is information I've gleaned from either their websites or from people such as Anna who have written to them for more details. It is by no means complete, but it provides a framework for comparing these clinics. Guy, if you'd like access to the Library on Google Drive, send me an email (my email address on User Information page).

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    2. wwww26 May 2016 at 08:34

      Stephen, I would love if you can add me to your goole drive. wwww8078@gmail.com. Please let me know -i don't see where to find your email.

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    3. Galya13 February 2017 at 12:19

      Dear Guy/ Stephan/All, if possible can i have access to the document that summarizes patient information for the Duderstadt, IOZK, Unifontis and Hallwang. I am new to these discussions and would greatly appreciate the info. my email galya.dimitrova@gmail.com.Thank you so very much!

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    4. Stephen W13 February 2017 at 16:26

      I sent you an invite to the Brain Tumor Library. The document you're looking for is in folder 0 (Reference documents), "German immunotherapy clinics" subfolder.

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