Temodar in the morning or in the evening with melatonin.
I have seen lots of publications stating that melatonin can overcome multidrug resistance to tmz. I am wondering if any of you are taking tmz at night with melatonin or are all of you taking it in the morning and what would be a good strategy.
Unfortunately this study was using ridiculously high concentrations of melatonin, 1 mM, which is approximately 10,000 times the maximal plasma levels after a 20 mg dose.
My NO is having me take my maintenance TMZ at night before bed and 1 hour after all other pills and food. So I take my Melatonin (20mg) 1 hour before my TMZ at night along with all my other supplements and drugs.
When I was on TMZ during my radiation treatments, I took my TMZ in the mornings and Melatonin at night before bed.
Perhaps you're referring to this study?
ReplyDeletehttp://www.nature.com/bjc/journal/v108/n10/pdf/bjc2013188a.pdf
Unfortunately this study was using ridiculously high concentrations of melatonin, 1 mM, which is approximately 10,000 times the maximal plasma levels after a 20 mg dose.
We do 20mg at 7pm and Temodar at 8:00 PM. Not sure if it's effective - MRI isn't for a few more weeks.
DeleteMy NO is having me take my maintenance TMZ at night before bed and 1 hour after all other pills and food. So I take my Melatonin (20mg) 1 hour before my TMZ at night along with all my other supplements and drugs.
ReplyDeleteWhen I was on TMZ during my radiation treatments, I took my TMZ in the mornings and Melatonin at night before bed.
Marc