My brother also has giant cell glioblastoma. I think it does have a bit better prognosis. Somebody somewhere said that optune might now work as well on giant cells, but I'm not sure if it is true because clinical trials with optune do take patients with giant cell glioblastoma too.
According to what I've read, giant cell GBM is a rare GBM variant characterized by large multinucleated cells. TP53 mutations are much more common in gcGBM than non-giant cell GBM. It has been shown that the loss of p53 function (with mutation) combined with dysregulation of Aurora-B kinase leads to the giant multinucleated cell population.
Prognosis is somewhat improved, with a higher number of long-term survivors. The improved prognosis may be due to increased sensitivity to TMZ+RT or younger average age, or other unknown factors may be involved. Not much is known about this subtype as it is rare.
My brother also has giant cell glioblastoma. I think it does have a bit better prognosis. Somebody somewhere said that optune might now work as well on giant cells, but I'm not sure if it is true because clinical trials with optune do take patients with giant cell glioblastoma too.
ReplyDeleteAccording to what I've read, giant cell GBM is a rare GBM variant characterized by large multinucleated cells. TP53 mutations are much more common in gcGBM than non-giant cell GBM. It has been shown that the loss of p53 function (with mutation) combined with dysregulation of Aurora-B kinase leads to the giant multinucleated cell population.
ReplyDeletePrognosis is somewhat improved, with a higher number of long-term survivors. The improved prognosis may be due to increased sensitivity to TMZ+RT or younger average age, or other unknown factors may be involved. Not much is known about this subtype as it is rare.
Anna, is your brother young? I was diagnosed with gcGBM at the age of 31.
ReplyDeleteHe is 47 or so I forgot
ReplyDelete