Tuesday 20 October 2015
Disulfiram and DCA
After Jeremy finishes his 12th round of TMZ end of next month I plan on having his take disulfiram on a daily basis in an attempt to go after CSC's. Who is using both disulfiram and DCA concurrently and are you have any difficulties with PN? Are you rotating on and off disulfiram? The question that comes to my mind is whether disulfiram use intermittently will result is disulfiram resistant CSC (assuming it works at all). Sort of like taking an antibiotic for a bacterial infection might result in antibiotic resistant bacteria if the drug is not taken for a long enough duration. But then this has to be considered in light of developing PN. Additionally, what dose of disulfiram is being used with those combining DCA wand disulfiram? Any thoughts will be much appreciated. Thanks in advance.
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Hi Mike.
ReplyDeleteWe are using both Disulfiram and DCA but we are very inconsistent with it and we don't have a plan how to use it yet. Initially we used it only during chemo, then 250 mg per day every day then we stopped and now we are way up to 500 per day. We don't have a plan yet how we will use it just for now since we have a recurrence we take a lot of it to slow the tumor as much as possible so my brother makes it till we have the vaccine ready. Manufacturing peptide vaccine can take up to 3 months so as long as we don't have any side effects we will stay at the higher dosage for a while.