Tuesday 27 October 2015

Chloroquine and caloric restriction

According to this study with mice bearing melanoma xenografts, chloroquine works nicely with caloric restriction.

http://static-content.springer.com/image/art%3A10.1007%2Fs11095-012-0753-1/MediaObjects/11095_2012_753_Fig6_HTML.gif


CQ = chloroquine
CR = caloric restriction (mice were given 70% of their normal daily caloric intake)

Caloric restriction to the point of losing weight can't be sustained indefinitely of course, but such a strategy might work well during critical times, such as during the 6 weeks of chemoradiation.

Images from:

Chloroquine-mediated lysosomal dysfunction enhances the anticancer effect of nutrient deprivation.


I'll add this study to the Brain Tumour Library
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1 comment:

  1. Stephen W27 October 2015 at 16:56

    Chloroquine was also synergistic with disulfiram in prolonging the lives of mice with malaria, thought the relevance of this to cancer is uncertain.

    "Potentiation of the antimalarial action of chloroquine in rodent malaria by drugs known to reduce cellular glutathione levels"

    http://www.ncbi.nlm.nih.gov/pubmed/12948862

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