Metformin and temozolomide act synergistically to inhibit growth of glioma cells and glioma stem cells in vitro and in vivo (click on this link)
Unfortunately this was another flank-injected, non-orthotopic mouse model, and used an overly high metformin dose of 400 mg/kg mouse body weight. The mice were immunodeficient SCID mice. Still, most of us here are using metformin anyway, so this is additional encouragement. See especially figure 7A on page 10.
No comments:
Post a Comment