Friday 24 May 2019


Vladimir’s healing cocktail



Hello to everyone!


I’ve just learnt about this great blog and would like to get some useful information and advice about my father-in-law’s treatment.

Vladimir M., 71 years.
He was diagnosed with glioblastoma (Grade IV), frontal area, size 52 mm*39 mm *23mm, operated on 21/05/19. After the resection, he was O’K. I mean he could speak, walk, he remembered everything. At the moment he is receiving dexamethasone injections (4 mg./3 times a day).  

Histology results: 
- glioblastoma;
- positive reaction to GFAP;
- Ki-67 index - 25%;
- negative to SYN, IDH, ki-67 10-12%

Now we are waiting for radiation and TMZ (probably started in 2 weeks).
I’m a little bit frustrated at the moment about what medicine to start with to make the treatment most effective. Stephen’s list contains such a lot of drugs that I cannot decide which of them should be included in our drug cocktail.
What do you think about this cocktail?

Drug
Dosage
For how long time should the patient take these drugs?
Keppra
1000 mg.
hydroxychloroquine
400mg daily
Metformin
500mg
Celebrex
200-400mg daily
Mebendezole 100 mg for 3 months + Doxycycline 100 mg for 1 month
Do we actually need it or it’s excessive?


Supplements
Dosage

Boswellia (Wokvel Brand)
500-1000mg

Green Tea or Extract
700 mg 40% EGCG

Molybdenum Glycenate
1g

Berberine
500-100mg daily (divided doses)

Melatonin
10-20 mg.

Omega 3 Fish Oil
tbd

Probiotic
tbd

Quercetin
865 mg

Bromelain
500 mg

Marrow Plus
tbd

Milk thistle
1000-2000mg


1)    Is there anything you would suggest I add or remove?
2)    When do we have to start taking these drugs? Right now or during radiation?
3)    Is it OK if we start taking supplements a week later after the drugs (I need some time to get them from USA to Russia)?
Thanks to everyone for your help

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2 comments:

  1. Stephen W26 May 2019 at 11:52

    Hi Tatiana,
    For now I would focus on assembling a radiation-focused cocktail. I have summarized some evidence here:

    http://astrocytomaoptions.com/radiation/

    High doses of valproic acid/valproate/Depakote may act as a radiosensitizer. In the phase 2 trial that I described in the link above, they started at a dose of 10-15 mg Depakote per kg of body weight, one week before the start of radiation, and increased to a dose of 25 mg/kg by the first day of radiation. Depakote is an anti-seizure agent. This dose of the drug is higher than what many people might need to prevent seizures, but the higher dose might be necessary for anti-tumor activity.

    If he has already had seizures that are being controlled by Keppra, then you would have a reason to stay with Keppra. But otherwise higher-dose valproic acid/Depakote during radiation might be better from an anti-tumor standpoint.

    https://www.ncbi.nlm.nih.gov/pubmed/26194676

    There is a small case series showing that Keppra may inhibit MGMT expression, so one idea would be to re-initiate Keppra during the high dose monthly cycles of TMZ.

    Carb-restricted diets (such as ketogenic diet) might have the most effect if done during the 6 weeks of radiation.

    If he could have his tumor sample tested for EGFR amplification, and the EGFRvIII mutation (these are relatively common in GBM), that would also be useful information. Chloroquine may be especially beneficial for tumors with these EGFR alterations.

    100 mg per day of mebendazole would likely be very well tolerated. I have strong doubts such a low dose would have anti-tumor activity due to the low bioavailability of the drug. Clinical trials of mebendazole for high-grade brain tumors have started at a dose of 500 mg, three times daily (1500 mg per day in total), and gone up from there.

    Mebendazole + doxycycline makes me think of Care Oncology protocol. I hope they publish full details of their trial soon (or at least the GBM part of it), because lots of people are interested in it, but they haven't published enough details to actually say it works or not.

    I would definitely use Celebrex (or other COX-2 inhibitor) during and after radiation, to prevent the pro-invasive and immunosuppressive effects of PGE2, which is increased in the tumor following radiation (see the Radiation article above).

    I would also try at least 1000 mg Wokvel per day if you can get it (3 caps per day). This will hopefully have steroid-sparing effects (reducing the need for dexamethasone).

    I don't see a reason to wait until radiation starts to initiate supplements.

    Yes it's probably better not to start everything all at once, but to introduce things one by one. That way if there is an adverse reaction (side-effect) it will be easier to identify the cause.

    ReplyDelete
  2. Tatiana27 May 2019 at 12:09

    Dear Stephen!
    Thank you so much for your immediate and so quick response. Words cannot express fully my gratitude to you!
    Now I know what to start with.
    I wish good health to you and all those who suffer from this serious disease.

    ReplyDelete

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