Sunday 17 May 2020

Mebendazole, recommended phase 2 dose in high grade glioma

https://www.ncbi.nlm.nih.gov/pubmed/32400117
Reverse swing-M, phase 1 study of repurposing mebendazole in recurrent high-grade glioma.

"Interpretation: The recommended phase 2 dose of mebendazole is 1600 mg TDS with temozolomide and temozolomide-radiation combination while the dose of 800 mg TDS needs to be used with single-agent CCNU."

TDS apparently means three times daily, so 1600 mg TDS = 4800 mg per day total.


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