Everybody is taking temozolomide and after that avastin. When I spoke to few doctors none of them offered lomustin. Is there a reason why doctors don't offer it? Is it because of side effects? We know that it worked very well for Benn in combination with verapamil.
Since there is no single "standard of care" for recurrent GBM, you will find recommendations vary from hospital to hospital. I know plenty of recurrent GBM patients who've been given lomustine (CCNU). Avastin + CCNU is becoming the unofficial standard in some centers, since the BELOB trial. It is an alkylating agent (more specifically a chloroethylating agent), and not likely to be particularly helpful for MGMT unmethylated tumors, unless MGMT is pharmacologically inhibited (which in theory would be disulfiram, Keppra, Prozac etc). Ben's tumor was MGMT methylated.
ReplyDeleteHi Anna, mi wife was on PCV protocol, after 1 round the tumor looked stabilized, but in the secound round it caused myelosupression, she received 2 units of blood and in the next control MRI a massive cyst grewth side the original tumor. Our NO surprised about the use of PCV due to his toxicity, in my wife case, he was right. My wife now is on 50mg/m2 tmz metronomic.
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